Results 11 to 20 of about 9,876,006 (204)

Secondary findings in 421 whole exome-sequenced Chinese children

Human Genomics, 2018
Background Variants with known or possible pathogenicity located in genes that are unrelated to primary disease conditions are defined as secondary findings.
Wen Chen, Wenke Li, Yi Ma, Yujing Zhang, Bianmei Han, Xuewen Liu, Kun Zhao, Meixian Zhang, Jie Mi, Yuanyuan Fu, Zhou Zhou   +10 more
doaj   +2 more sources

Secondary findings from whole-exome sequencing data in families with familial combined hyperlipidemia (FCHL)

Egyptian Journal of Medical Human Genetics, 2021
Background During the interpretation of genome sequencing data, some types of secondary findings are identified that are located in genes that do not appear to be related to the causes of the primary disease.
Mana Zakeri, Mohammad Sadegh Safaiee, Forough Taheri, Eskandar Taghizadeh, Gordon A. Ferns, Majid Ghayour Mobarhan, Alireza Pasdar   +6 more
doaj   +2 more sources

SDHA secondary findings in germline testing: counseling and surveillance considerations [PDF]

Endocrine Oncology
This commentary explores the complexities faced by clinicians when encountering a secondary SDHA pathogenic variant (PV) in patients without a personal or family history of SDHA-related tumors.
Catherine M Skefos, Pamela L Brock, Erica Blouch, Samantha E Greenberg   +3 more
doaj   +2 more sources

Preference for secondary findings in prenatal and pediatric exome sequencing [PDF]

, 2022
OBJECTIVE: We aimed to determine the frequency of accepting secondary findings in families undergoing exome sequencing in prenatal and pediatric settings.
Shannon Rego, Chen, Flavia, Billie R. Lianoglou, Patel, Sachi, Jessica Van Ziffle, Lianoglou, Billie R, Rego, Shannon, Tiffany Yip, Slavotinek, Anne M, Kate Swanson, Sachi Patel, Anne M. Slavotinek, Mary E. Norton, Sarah Downum, Flavia Chen, Sparks, Teresa N, Van Ziffle, Jessica, Swanson, Kate, Barbara A. Koenig, Downum, Sarah, Norton, Mary E, Koenig, Barbara A, Yip, Tiffany, Teresa N. Sparks   +23 more
core   +1 more source

A qualitative examination of factors related to the decrease in physical activity behavior in adolescent girls during the transition from primary to secondary school [PDF]

, 2011
Background: Quantitative research has suggested that the decline in physical activity levels for adolescent girls is most marked during the transition from primary school to secondary school yet understanding the contributing factors for this decline may
Niven, Ailsa, Knowles, Ann-Marie, Fawkner, Samantha   +2 more
core   +3 more sources

Secondary school students' attitudes to practical work in school science [PDF]

, 2012
Practical work is seen as having an important role in school science. In particular many have claimed that it has an essential role in determining students' attitudes to school science and science beyond the classroom. However, whilst there has been much
Sharpe, Rachael May
core   +5 more sources

Development of a novel measure of advanced cancer patients’ perceived utility of secondary germline findings from tumor genomic profiling

PEC Innovation, 2023
Objective: Tumor genomic profiling (TGP) can inform advanced cancer patients’ treatment decisions, and also reveal secondary germline findings—information about inherited risks for cancer and other disorders.
Jada G. Hamilton, Ibrahim H. Shah, Caroline Salafia, Elizabeth Schofield, Margaux Genoff Garzon, Kechna Cadet, Zsofia K. Stadler, Jennifer L. Hay, Kenneth Offit, Mark E. Robson   +9 more
doaj   +1 more source

From Targeting Somatic Mutations to Finding Inherited Cancer Predispositions: The Other Side of the Coin

Diagnostics, 2019
The expanding use of tumor genome analysis by next generation sequencing to drive target therapies has led to increased germline findings in genes predisposing to hereditary cancer.
Pascal Pujol, Thibault De La Motte Rouge, Frédérique Penault-Llorca   +2 more
doaj   +1 more source

Revisiting Secondary Information Related to Pharmacogenetic Testing

Frontiers in Genetics, 2021
Incidental or secondary findings have been a major part of the discussion of genomic medicine research and clinical applications. For pharmacogenetic (PGx) testing, secondary findings arise due to the pleiotropic effects of pharmacogenes, often related ...
Susanne B. Haga
doaj   +1 more source

Miles away. Determining the extent of secondary task interference on simulated driving [PDF]

, 2007
There is a seemingly perennial debate in the literature about the relative merits of using a secondary task as a measure of spare attentional capacity.
Young, Mark S., Stanton, Neville A., Stanton, NA, Young, MS   +3 more
core   +1 more source