Results 51 to 60 of about 132,272 (225)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Frontiers in PharmacologyObjectiveThis study aimed to evaluate the efficacy and safety of antiepileptic drugs and non-pharmacological treatments in patients with Lennox-Gastaut syndrome (LGS).MethodsWe conducted a systematic search of the PubMed, Embase, Cochrane, and Web of ...
Zhengyan Zhu +10 more
doaj +1 more source
Research on fast response criterion of power grid distributed loads after HVDC block fault
IET Generation, Transmission & Distribution, 2020 The system equivalent inertia of the power grid is gradually decreased with the increasing penetration of renewable energy resources, which leads to a higher risk of frequency fluctuation after a major fault.
Yuling Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Zhejiang dianliConventional stepwise inertial control （SIC） is decoupled from grid frequency， which limits the real-time frequency perception of wind turbines and may lead to severe secondary frequency drop （SFD）.
ZHOU Tao +4 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Design of a novel vortex-based feedback fluidic oscillator with numerical evaluation
Engineering Applications of Computational Fluid Mechanics, 2020 In this study, a new vortex-based fluidic oscillator was designed whose performance was numerically evaluated by solving the URANS equations. The oscillator consists of a primary chamber and secondary chamber, separated by a mid-throat and connected by ...
Mahdi Nili-Ahmadabadi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source