Results 181 to 190 of about 9,246,101 (265)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Photoperiod and temperature as dominant environmental drivers triggering secondary growth resumption in Northern Hemisphere conifers. [PDF]

Proc Natl Acad Sci U S A, 2020
Huang JG, Ma Q, Rossi S, Biondi F, Deslauriers A, Fonti P, Liang E, Mäkinen H, Oberhuber W, Rathgeber CBK, Tognetti R, Treml V, Yang B, Zhang JL, Antonucci S, Bergeron Y, Camarero JJ, Campelo F, Čufar K, Cuny HE, De Luis M, Giovannelli A, Gričar J, Gruber A, Gryc V, Güney A, Guo X, Huang W, Jyske T, Kašpar J, King G, Krause C, Lemay A, Liu F, Lombardi F, Martinez Del Castillo E, Morin H, Nabais C, Nöjd P, Peters RL, Prislan P, Saracino A, Swidrak I, Vavrčík H, Vieira J, Yu B, Zhang S, Zeng Q, Zhang Y, Ziaco E.   +49 more
europepmc   +1 more source

Theories with Regard to Secondary Growths in Carcinoma of the Breast [PDF]

BMJ, 1912
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Deciphering the Molecular Mechanism of the Intermediate Secondary Growth and Internode Elongation of the Castor Bean (Ricinus communis L.) by the Combined Analysis of the Transcriptome and Metabolome. [PDF]

Int J Mol Sci
Chen Y, Orlov YL, Chen M.
europepmc   +1 more source

Observed coupling between air mass history, secondary growth of nucleation mode particles and aerosol pollution levels in Beijing.

Environ Sci Atmos, 2022
Hakala S, Vakkari V, Bianchi F, Dada L, Deng C, Dällenbach KR, Fu Y, Jiang J, Kangasluoma J, Kujansuu J, Liu Y, Petäjä T, Wang L, Yan C, Kulmala M, Paasonen P.   +15 more
europepmc   +1 more source

DNA methylation and its effects on gene expression during primary to secondary growth in poplar stems. [PDF]

BMC Genomics, 2020
Zhang Y, Liu C, Cheng H, Tian S, Liu Y, Wang S, Zhang H, Saqib M, Wei H, Wei Z.   +9 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source