Results 131 to 140 of about 5,179,156 (340)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improving the health of people with multimorbidity: the need for prospective cohort studies [PDF]

, 2011
The dramatic rise in long-term conditions (LTCs) represents a major challenge for individuals, families, and health care systems worldwide. Due to the scale of this rise, the management of patients with LTCs largely falls within the domain of primary ...
Gunn, J., Mercer, S.W., Wyke, S.
core   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Determinants of the choice of health care facility utilised by individuals in HIV/AIDS-affected households in the Free State province of South Africa [PDF]

This paper analyses differences in the choice of health care facility by individuals in HIV/AIDS-affected households in the Free State province of South Africa. Illness is more prevalent and severe amongst poorer affected households. The probability that
Frikkie Booysen, Martine Visser
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Comparison of Knowledge, Attitude, and Practices of Nursing Staff Regarding Cervical Cancer Screening at Various Levels of Health Care Facilities in Western India

Indian Journal of Community Medicine
Background: Cervical cancer is a public health problem, and nursing personnel are crucial for successful implementation of low-cost cervical cancer screening approaches in low-resource settings.
Rashmi Kaushal, Mamta Patel, Pankaj Bhardwaj, Manoj Gupta, Deepti Mathur, Girish Chandra Dash, Shashank Shekhar   +6 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Health Care Network: Maternal perception regarding the quality of care to children with microcephaly

Escola Anna Nery, 2019
Objective: To identify the perception of primary caregivers on the quality of the Health Care Network of children with microcephaly related to congenital infection. Methods: A cross-sectional study carried out from October 2017 to April 2018.
Daniel Batista Conceição dos Santos, Elaine Ferreira da Silva, Sonia Oliveira Lima, Francisco Prado Reis, Cristiane da Costa Cunha Oliveira   +4 more
doaj   +2 more sources

Baseline study for improving diagnostic stewardship at secondary health care facilities in Nigeria. [PDF]

Antimicrob Resist Infect Control, 2022
Egwuenu A, Ejikeme A, Tomczyk S, von Laer A, Ayobami O, Odebajo O, Akhibi S, Agulanna C, Osagie O, Inweregbu US, Yahaya R, Okwor T, Dada-Adegbola H, Ajayi I, Olorukooba A, Eckmanns T, Ochu CL, Ihekweazu C.   +17 more
europepmc   +1 more source

Initial Experiences of Building Secure Access to Patient Confidential Data via the Internet [PDF]

, 2000
A project to enable health care professionals (GPs, practice nurses and diabetes nurse specialists) to access, via the Internet, confidential patient data held on a secondary care (hospital) diabetes information system, has been implemented.
Chadwick, David W., Harvey, S., New, John, Young, Andrew J.   +3 more
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