Results 191 to 200 of about 5,179,156 (340)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A school-based, multi-faceted health promotion programme to prevent obesity among children: protocol of a cluster-randomised controlled trial (the DECIDE-Children study)

BMJ Open, 2019
, Qin Li, Hong Zhou, Fang Zhang, Zheng Liu, Pei Gao, Yangfeng Wu, Yi Song, Shuang Zhou, Wen-Yi Niu, Xiangxian Feng, Yi Lin, Aiyu Gao, Hai Fang, Hui-Juan Li, Haijun Wang, Hai-Jun Wang, Li-Zi Lin, Qiang Feng, Chen-Xiong Li, Wen-Hao Li, Chu-Yao Jin, Yu Cheng, Lan Cheng Di Wang, Xiang-Rong Xu, Jie-Yun Song, Ai-Yu Gao, Hai-Hua Chen, Li-Jia Shang, Run-Ze Chen, Xiang-Xian Feng, Jian-hui Yuan, Li-fen Duan, Chun-Xia Xu, Guo-Qin Yang, Zheng Zhang   +35 more
doaj   +1 more source

Morbilidad por tuberculosis: aspectos epidemiológicos, clínicos y diagnósticos. Santiago de Cuba. 2007-2011

Medisan
Se realizó un estudio descriptivo y transversal de los 323 casos con diagnóstico confirmado de tuberculosis en la provincia de Santiago de Cuba, con vistas a caracterizar la incidencia de esta enfermedad en el período 2007-2011, para lo cual se ...
Lázaro I Romero García, Pedro A Bacardí Zapata, Yordanys Paez Candelaria, Karima M Gondres Legró, Digna de la C Bandera Jiménez   +4 more
doaj  

Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study

Genetics in Medicine, 2018
Ragan Hart, B. Biesecker, C. Blout, K. Christensen, K. Christensen, L. Amendola, Katie Bergstrom, Sawona Biswas, K. Bowling, L. Conlin, L. Conlin, Greg M. Cooper, M. Dulik, M. Dulik, K. East, Jessica N Everett, C. Finnila, A. Ghazani, Marian J Gilmore, K. Goddard, G. Jarvik, J. Johnston, T. Kauffman, W. Kelley, J. Krier, K. Lewis, A. McGuire, C. McMullen, Jeffrey Ou, S. Plon, H. L. Rehm, H. L. Rehm, H. L. Rehm, C. Richards, Edward J. Romasko, Ane Miren Sagardia, N. Spinner, M. Thompson, E. Turbitt, J. Vassy, J. Vassy, J. Vassy, B. Wilfond, D. Veenstra, J. Berg, R. C. Green, L. Biesecker, L. Hindorff   +47 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Association of Palliative Care Decision on Secondary Health Care Utilization and Cancer Treatment at the End of Life Among Patients with Head and Neck Cancer: A Single-Center Retrospective Study. [PDF]

Health Serv Insights
Merikari M, Saarto T, Leskelä RL, Mäkitie A, Carpén T, Akrén O.   +5 more
europepmc   +1 more source

Do the Poor Benefit from Public Spending? A Look at the Evidence [PDF]

This paper shows that public spending on basic services, to wit, primary and secondary education and basic health care, benefit the poor; while the non-poor are the principal beneficiaries of tertiary and education subsidies and hospital spending.
John Gafar
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source