Results 31 to 40 of about 12,621 (181)

Secondary lymphedema: Pathogenesis

Journal of Skin and Sexually Transmitted Diseases, 2021
Secondary lymphedema follows an acquired defect in the lymphatic system. The common causes leading to a defective lymphatic function include infection, inflammation, malignancy, trauma, obesity, immobility, and therapeutic interventions. Understanding the pathogenesis of lymphedema is of prime importance in offering effective treatment.
openaire   +1 more source

Quality of Life Outcomes in Lower Extremity Lymphedema After Manual Lymphatic Drainage Therapy

Bagcilar Medical Bulletin
Objective: Lymphedema is a complex condition, and there is limited evidence regarding the impact of lower extremity lymphedema on patients’ health and quality of life (QoL).
Sedef Ersoy, Büşra Şirin Ahısha, Nur Kesiktaş, Cansın Medin Ceylan, Nurdan Paker, Derya Buğdaycı, Eser Kalaoğlu   +6 more
doaj   +1 more source

A rare truncal collateral lymph drainage pathway seen on indocyanine green lymphography in patients with secondary lower limb lymphedema

Journal of Vascular Surgery Cases and Innovative Techniques, 2023
Objective: Although collateral lymphatic vessels are known to develop in patients with lymphedema, little is known about their significance. In this study, we investigated truncal collateral lymphatic drainage pathways in patients with lower limb ...
Solji Roh, MD, Isao Koshima, MD, PhD, Toshiro Mese, MD, Hirofumi Imai, MD, Shuhei Yoshida, MD, PhD, Shuji Yamashita, MD, PhD   +5 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment of Reepithelialization (SNARE) and perform parametric testing including ...
Rohan Bellary, Zakaria Dairi, Niraj Rama, Jennifer Kreinik, Thomas S. Higgins, Taylor Carle, Arthur W. Wu, Dilpreet Mann, Jennifer K. Mulligan, Brian Lobo, Christopher Ito, Elisa A. Illing, Satyan B. Sreenath, Martin J. Citardi, Christopher Roxbury, Raj Sindwani, Edward McCoul, Jeffrey Suh, Daniel Beswick, Philip G. Chen, Dennis M. Tang   +20 more
wiley   +1 more source

Topical captopril: a promising treatment for secondary lymphedema. [PDF]

Transl Res, 2023
Transforming growth factor-beta 1 (TGF-β1)-mediated tissue fibrosis is an important regulator of lymphatic dysfunction in secondary lymphedema. However, TGF-β1 targeting can cause toxicity and autoimmune complications, limiting clinical utility. Angiotensin II (Ang II) modulates intracellular TGF-β1 signaling, and inhibition of Ang II production using ...
Brown S, Nores GDG, Sarker A, Ly C, Li C, Park HJ, Hespe GE, Gardenier J, Kuonqui K, Campbell A, Shin J, Kataru RP, Aras O, Mehrara BJ.   +13 more
europepmc   +3 more sources

Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Postoperative radiotherapy is the standard treatment for locally advanced oral squamous cell carcinoma (OSCC); however, the indication for neck irradiation (NI) in pN0 patients remains debatable. We evaluated whether the omission of NI compromises outcomes in pT3–T4 pN0 patients treated with adequate neck dissection (ND).
Mathilde Mirallié, Anouchka Modesto, Marie Pajiep, Sébastien Vergez, Jérôme Sarini, Lucie Piram, Céline Dalmasso, Benjamin Vairel, Emilien Chabrillac, Agnès Dupret‐Bories   +9 more
wiley   +1 more source

Treatment With the Shaker Head‐Lift Exercise in Head and Neck Cancer Patients With Radiation‐Induced Dysphagia: 12‐Month Results on Swallowing Function From a Randomized, Controlled Trial

Head &Neck, EarlyView.
ABSTRACT Background Dysphagia is a common side‐effect after radiotherapy in head and neck cancer patients. This randomized study aimed to evaluate the effect of the shaker head‐lift exercise (HLE) after 12 months with flexible endoscopic evaluation of swallowing (FEES). Methods Patients were randomly assigned to the intervention (n = 30) or the control
Signe Rödseth Smith, Caterina Finizia, Kerstin Petersson, Lisa Tuomi   +3 more
wiley   +1 more source

Secondary Lymphedema [PDF]

DeckerMed Vascular and Endovascular Surgery, 2020
V. Suzanne Klimberg, Daniela Ochoa
openaire   +2 more sources

Treatment with YIGSR peptide ameliorates mouse tail lymphedema by 67 kDa laminin receptor (67LR)-dependent cell-cell adhesion

Biochemistry and Biophysics Reports, 2023
Impaired microcirculation can cause lymphatic leakage which leads to a chronic swelling in the tissues of the body. However, no successful treatment gives any protection against lymphedema due to the lack of well-revealed pathophysiology of secondary ...
Y. Sakae, H. Takada, S. Ichinose, M. Nakajima, A. Sakai, R. Ogawa   +5 more
doaj   +1 more source