Results 161 to 170 of about 790,254 (306)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Bempedoic Acid in Secondary Prevention

American Journal of Preventive Cardiology
Idine Mousavi, Vijay Nambi, Layla A. Abushamat, Sadeer G. Al-Kindi, Michael D. Shapiro, Laurence Sperling, Salim S. Virani, Abdul Mannan Khan Minhas   +7 more
doaj   +1 more source

Utilization and discontinuation of secondary prevention pharmacotherapy after myocardial infarction: a nationwide cohort study. [PDF]

Eur Heart J Cardiovasc Pharmacother
Yari A, Lim CE, Hagström E, Lundman P, Schubert J, Jernberg T, Ueda P.   +6 more
europepmc   +1 more source

Role of the polypill for secondary prevention in ischaemic heart disease [PDF]

, 2017
José M. Castellano, Valentı́n Fuster, Catriona Jennings, Eva Prescott, Héctor Bueno   +4 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Factor XI/XIa Inhibitors: Promising Agents for the Secondary Prevention of Ischemic Stroke [PDF]

Balkan Med J
Atmaca MM.
europepmc   +1 more source

Prevention of tobacco-free nicotine products in adolescents at secondary school : - An interview study among school nurses

, 2023
Börjesson, Malin, Jäger, Cecilia
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Blood pressure management in secondary prevention after myocardial infarction. [PDF]

Cardiovasc Res
Volpe M, Gallo G, Guzik TJ, Williams B, Messerli FH.   +4 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source