Results 201 to 210 of about 26,876 (262)

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Subgrain and Cavity Development during Creep of Al‐3.85%Mg

Advanced Engineering Materials, EarlyView.
Al‐3.85%Mg does form subgrains if crept at very high strains. This fact allows the unification of the creep description in two different alloys such as pure Al and Al–Mg alloys. It is classically considered that the creep mechanisms for type M (e.g., pure Al) and type A alloys (e.g., Al–Mg alloys) are different.
Augusta Isaac, Itziar Serrano‐Munoz, Aleksander Kostka, Martinus Putra Widjaja, Gaspar González‐Doncel, Giovanni Bruno, Ricardo Fernández   +6 more
wiley   +1 more source

Advancing Wildfire‐Retardant Materials: Engineering Strategies for Direct and Indirect Suppression

Advanced Engineering Materials, EarlyView.
Here, the evolution, ecological impact, and performance of current fire‐retardant materials and suppression strategies are reviewed, offering an engineering perspective to address existing challenges and propose pathways for the development of more effective, scalable, and sustainable solutions to meet the demands of a changing climate. Wildfires cause
Changxin Dong, Samya Sen, Athena Kolli, Stewart G. Wilson, Eric Andrew Appel   +4 more
wiley   +1 more source

Mitigation of Cracks in High‐Performance Nickel‐Based Superalloys in Powder Bed Fusion Laser Beam of Metals Using a Metal Matrix Composite Approach

Advanced Engineering Materials, EarlyView.
High‐performance nickel‐based superalloys are often not processible in additive manufacturing (AM) due to hot cracking. The findings in this manuscript propose an efficient method to mitigate cracking and enhance mechanical properties of these alloys by producing a metal matrix composite, contributing to the material and process perspective of the AM ...
Klaus Büßenschütt, Maël Pontoreau, Christian Haase, Johannes‐Henrich Schleifenbaum   +3 more
wiley   +1 more source

Primary and Secondary Prevention of Colorectal Cancer

Clinical Medicine Insights: Gastroenterology, 2014
Pedro J. Tárraga López, Juan Solera Albero, José Antonio Rodríguez-Montes   +2 more
doaj  

Secondary Fracture Prevention [PDF]

Current Osteoporosis Reports, 2012
Osteoporosis causes no symptoms until there is a fracture. Although screening for osteoporosis is recommended for some populations, patients may present with a fragility fracture. Such patients are at high risk for subsequent fractures. Despite this high risk and the presence of generally safe and effective osteoporosis therapy, only a minority of low ...
Robert A. Adler, Robert A. Adler
openaire   +2 more sources

Secondary stroke prevention [PDF]

The Lancet Neurology, 2014
Survivors of stroke and transient ischaemic attacks are at risk of a recurrent stroke, which is often more severe and disabling than the index event. Optimum secondary prevention of recurrent stroke needs rapid diagnosis and treatment and prompt identification of the underlying cardiovascular cause.
openaire   +2 more sources