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Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma
Frontiers in Pharmacology, 2019 Objectives: Asthma is a chronic airway inflammatory disease, which is characterized by airway remodeling, hyperreactivity and shortness of breath. Paeoniflorin is one of the major active ingredients in Chinese peony, which exerts anti-inflammatory and ...Qiyang Shou, Qiyang Shou, Qiyang Shou, Lu Jin, Lu Jin, Jiali Lang, Jiali Lang, Qiyuan Shan, Zhunan Ni, Changpei Cheng, Qinglin Li, Huiying Fu, Gang Cao +12 moredoaj +1 more sourceVorapaxar in the Secondary Prevention of Atherothrombotic Events [PDF]
New England Journal of Medicine, 2012 Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1.We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive ...Morrow D. A., Braunwald E., Bonaca M. P., Ameriso S. F., Dalby A. J., Fish M. P., Fox K. A. A., Lipka L. J., Liu X., Nicolau J. C., Ophuis A. J. O., Paolasso E., Scirica B. M., Spinar J., Theroux P., Wiviott S. D., Strony J., Murphy S. A., McCabe C. H., Morin S., Lamp J., Gershman E., Deenadayalu N., Skene A., Hill K., Bennett L., Plat F., Berman G., Kilian A., He W., Aylward P., Bassand J. P., Betriu A., Bounameaux H., Corbalan R., Creager M., De Ferrari G., Dellborg M., Diehm C. H., Dietz R., Goto S., Grande P., Hankey G., Isaza D., Jensen P., Kiss R., Lewis B., Merlini P., Moliterno D., Morais J., Nieminen M., Nilsen D., Olin J., Ophuis T. O., Pichler M., Shinohara Y., Teal P., Tendera M., Thomassen L., Van de Werf F., White H., Wilcox R., Alberts M., Diener H., Mohr J., Welch M., Awtry E., Berger C., Desai A., Gelfand E., Ho C., Leeman D., Link M., Norden A., Pande A., Rost N., Ruberg R., Silverman S., Singhal A., Vita J., Frye R. L., Bailey K. R., Easton J., Hochman J., Steg P. G., Verheught F., Lee K., Mauro D. O., Centurion A., Carlevaro O., Cardozo E., Cartasegna L., Soccini N., Farras H. A., Molina Aguirre E., Duronto E., Arrechavala L., Rey R., Stilman A., Fernandez H., Marinsalta G., Tartaglione J., Chekherdemian M., Povedano G., Casares E., Kantor P., Reges P., Cuneo C., Martinez G., MacKinnon I., Bagnato B., Fernandez A., Funosas C., Lozada A., Barilati P., Ferrari J., Ferrari N., Llanos J., Casaccia G., Giannaula R., Garcia Mendez C., Cirio J., Garcia Davila C., Estol C., Chiezzo D., Ramirez J., Garrido S., Lopez M., Hominal M., Bianchini M. V., Ramos M., Verdini E., Herrera G., Monne H., Ioli P., Samudio M. A., Rotta Escalante R., Tarulla A., Reich E., Perez G., Milesi R., Berli M., Marino J., Funes I., Prado A., Bezi M., Fernandez R., Rojas M., Cimbaro Canella J. P., Galarza Salazan M., Chew D., Horsfall L., Claxton A., French J., O'Brien K., Nelson G., Loxton A., McCann A., Downey C., Aroney C., Cleave P., Worthley S., Roach A., Amerena J., Long A., Thompson P., Ferguson L., Fitzpatrick M., Mackenzie M., Youssef G., Goldsmith H., Jayasinghe R., Quinlan S., Arstall M., Rose J., Counsell J., Martin M., Crimmins D., Slattery A., Anderson C., Paraskevaidis T., Davis S., Silver G., Gerraty R. P., Gapper J., Donnan G., Petrolo S., Whelan A., Tulloch G., Singh B., Campo M. A., Dick R., Savage C., Hill A., Conway B., Waites J., Keays P., Kopp K., Hainzer D., Podczeck-Schweighofer A., Theurl M., Vandermeeren Y., Vanhooren G., Sinnaeve P., Chaves M. L., Miranda F., Tauil C. B., Faria Neto J. R., Welsh R., Rice T., Juri C., Jaramillo M., Urina M., Manzur F., Herzig R., Mikulik R., Bar M., Iversen H. K., Christensen H., Jensen M. K., Airaksinen J., Galinier M., Elbaz M., Timsit S., Suissa L., Quere I., Moulin T., Samson Y., Konstantinides S., Espinola-Klein C., Wuttig H., Dichgans M., Afanasiev S., Katz A., Marenzi G., Tritto I., Stramba-Badiale M., Berni A., Esposito G., Danzi G., Corrada E., Scrutinio D., Marcheselli S., Vatrano M., Agnelli G., Carugo S., Kubica J., Fiszer U., Ponikowski P., Roik M., Rynkiewicz A., Sobiczewski W., Kadziela J., Ramotowski B., Da Silva A., Coetsee E., Isasti G., Simal P., Arrarte Esteban V., Tembl J., Aladro Benito Y., Garcia-Moll X., Wahlgren C. M., Samad B., Mazzolai L., Gorog D., Wilmott R., Spratt J., Bath P., McDonough C., Lim M., Mansouri V., Schneider D. +272 moreopenaire +16 more sourcesAn Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey
Anatolian Journal of Cardiology, 2022 Background: The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study trial has been the largest study ever conducted among patients in Turkey regarding aspirin treatment.Kadriye Memiç Sancar, Oğuzhan Çelik, Cem Çil, Osman Karaarslan, Tolga Doğan, Mücahit Yetim, Ramazan Asoğlu, Yunus Çelik, Sedat Kalkan, Erkan Demirci, Emine Altuntaş, Gökay Taylan, Emrah Küçük, Zafer Küçüksu, Onur Aslan, Murat Civan, Özcan Başaran, Murat Bitekar +17 moredoaj +1 more sourceCardiac Prevention and Rehabilitation “3.0”: From acute to chronic phase. Position Paper of the ltalian Association for Cardiovascular Prevention and Rehabilitation (GICR-IACPR)
Monaldi Archives for Chest Disease, 2018 Cardiac rehabilitation (CR) is the subspecialty of clinical cardiology dedicated to the treatment of cardiac patients, early and in the long term after an acute event.Roberto F.E. Pedretti, Francesco Fattirolli, Raffaele Griffo, Marco Ambrosetti, Elisabetta Angelino, Silvia Brazzo, Ugo Corrà, Nicolò Dasseni, Pompilio Faggiano, Giuseppe Favretto, Oreste Febo, Marina Ferrari, Francesco Giallauria, Cesare Greco, Manuela Iannucci, Maria Teresa La Rovere, Mario Mallardo, Antonio Mazza, Massimo Piepoli, Carmine Riccio, Simonetta Scalvini, Luigi Tavazzi, Pier Luigi Temporelli, Gian Francesco Mureddu +23 moredoaj +1 more sourceSecondary Stroke Prevention in Women
Women's Health, 2011 In a meta-analysis of results from 21 randomized trials comparing antiplatelet therapy with placebo in 18,270 patients with prior stroke or transient ischemic attack, antiplatelet therapy was associated with a 28% relative odds reduction in nonfatal strokes and a 16% reduction in fatal strokes, while another trial for secondary prevention with ...Acciarresi M, De Rango P, Pezzella FR, Santalucia P, Amici S, PACIARONI, Maurizio, Mommi V, AGNELLI, Giancarlo, CASO, Valeria +8 moreopenaire +5 more sourcesSecondary prevention of sudden cardiac death
Heart Rhythm O2, 2020 The prevention and treatment of sudden cardiac death (SCD) remains a significant public health challenge. For patients with a history of sudden death attributable to ventricular arrhythmia, implantable cardioverter-defibrillator (ICD) therapy is a ...Neal A. Chatterjee, MD, MSc, Thomas D. Rea, MD, MPH +1 moredoaj +1 more sourceEvolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi +4 morewiley +1 more sourceEligibility for PCSK9 Inhibitors According to American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) Guidelines After Acute Coronary Syndromes
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundThe American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) have recently published recommendations for the use of proprotein convertase subtilisin/kexin‐9 (PCSK9) inhibitors in ...Baris Gencer, Konstantinos C. Koskinas, Lorenz Räber, Alexios Karagiannis, David Nanchen, Reto Auer, David Carballo, Sebastian Carballo, Roland Klingenberg, Dik Heg, Christian M. Matter, Thomas F. Lüscher, Nicolas Rodondi, François Mach, Stephan Windecker +14 moredoaj +1 more source
