Results 101 to 110 of about 1,706,928 (311)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Detracking Swedish Secondary Schools - Any Losers, Any Winners? [PDF]

Whether or not to differentiate - or track - students according to ability has been debated over the years. In Sweden, secondary schools that practiced tracking and schools that did not practice tracking existed simultaneously from 1980 to 1997.
Sund, Krister
core  

Responsibilities of subject mentors, professional mentors and link tutors in secondary physical education initial teacher education [PDF]

, 2003
Legislative changes in England, most notably the publication of Initial teacher training (Secondary phase) (Circular 9/92) by the Department for Education (DfE, 1992), have resulted in the reorganisation of initial teacher education (ITE), including the ...
Capel, S
core   +1 more source

School Climate as a Predictor of Secondary School Students’ School Attachment

Eurasian Journal of Educational Research, 2018
Problem Durumu: Egitim bireyin yasaminda onemli bir yere sahip olmakla birlikte, egitimin bireye verildigi okul ortaminin ozellikle okul ikliminin ogrenci bilissel, duyussal ve davranissal kazanimlarini etkilemektedir. Okul iklimini olusturan bilesenlerden biri de ogrencinin okula baglilik duzeyidir. Okula baglanma, ogrencinin okula, arkaladaslarina ve
Özgenel, Mustafa, Çalışkan Yılmaz, Filiz, Baydar, Feyza   +2 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Effective Pre-school, Primary and Secondary Education 3-14 Project (EPPSE 3-14): influences on students’ dispositions in Key Stage 3: exploring enjoyment of school, popularity, anxiety, citizenship values and academic self-concept in Year 9 [PDF]

, 2012
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has investigated the academic and social-behavioural development of approximately 3,000 children from the age of 3+ years since 1997.
Draghici, D., Melhuish, Edward C., Sammons, P., Siraj-Blatchford, I., Smees, R., Sylva, K., Taggart, B., Toth, K.   +7 more
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Mental health literacy and seeking for professional help among secondary school students in Slovakia: a brief report

Frontiers in Public Health
Secondary school students are at risk for mental health problems, especially nowadays, when we face an increase in mental health issues among adolescents and the general population.
Lenka Sokolová, Lenka Sokolová
doaj   +1 more source

VOCABULARY LEARNING STRATEGIES OF SECONDARY SCHOOL STUDENTS

IJOLTL: Indonesian Journal of Language Teaching and Linguistics, 2016
Strategy for learning vocabulary has an important role in English language acquisition. This study describes the vocabulary learning strategies that the students used when they learned new words. It attempted to find out if vocabulary learning strategies differed across school levels, gender, and ability groups as indicated by their English grades ...
openaire   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source