Results 101 to 110 of about 51,505 (219)

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

The FEBS Journal, EarlyView.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, Wai Li Ling, Jean‐Baptiste Reiser   +9 more
wiley   +1 more source

Probiotic stool secretory immunoglobulin A modulation in children with gastroenteritis: a randomized clinical trial. [PDF]

Am J Clin Nutr, 2021
Freedman SB, Horne R, Johnson-Henry K, Xie J, Williamson-Urquhart S, Chui L, Pang XL, Lee B, Schuh S, Finkelstein Y, Gouin S, Farion KJ, Poonai N, Hurley K, Schnadower D, Sherman PM, Pediatric Emergency Research Canada Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment (PROGUT) Trial Group.   +16 more
europepmc   +1 more source

Plant‐produced encapsulin displays non‐typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles

The FEBS Journal, EarlyView.
This study investigates the potential of encapsulin as an antigen display platform for the development of a candidate Salmonella vaccine for poultry. Encapsulin constructs were transiently expressed in Nicotiana benthamiana where they accumulated to high levels.
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Justin B. Renaud, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +6 more
wiley   +1 more source

Respiratory Mucosal Immunity: Kinetics of Secretory Immunoglobulin A in Sputum and Throat Swabs From COVID-19 Patients and Vaccine Recipients. [PDF]

Front Microbiol, 2022
Ren C, Gao Y, Zhang C, Zhou C, Hong Y, Qu M, Zhao Z, Du Y, Yang L, Liu B, Wang S, Han M, Shen Y, Liu Y.   +13 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Salivary assessment of the immune/inflammatory responses and oxidative stress in older adults vaccinated with CoronaVac or ChadOx-1

BMC Geriatrics
Background Although important information concerning COVID-19 vaccination is available, the effects of the CoronaVac and ChadOx-1 vaccines on immunity and the redox balance in the upper airway mucosa of the aged population are not fully understood ...
Jeniffer Vieira, Thiago Vinícius Vieira de Oliveira, Lorrayne Rithielle Rocha Queiroz, Camila Tussato Soares Camargo, Ariane Nardy, Fernanda Rodrigues Monteiro, Jônatas Bussador do Amaral, Vitória Paixão, Mauro Vaisberg, Gislene Rocha Amirato, Carlos André Freitas dos Santos, Edison Luiz Durigon, Danielle Bruna Leal Oliveira, Andressa Simões Aguiar, Anuska Marcelino Alvares-Saraiva, Débora Heller, Patricia Gabriela Viana Mantoanelli, Michelle Foigel Siqueira, Luiz Henrique da Silva Nali, André Luis Lacerda Bachi   +19 more
doaj   +1 more source

Circadian and homeostatic sleep-wake regulation of secretory immunoglobulin A (sIgA): Effects of environmental light and recovery sleep. [PDF]

Brain Behav Immun Health, 2022
Cajochen C, Weber J, Estrada AF, Kobayashi K, Gabel V.   +4 more
europepmc   +1 more source

Sex Differences in Health‐Related Quality of Life in Patients With Head and Neck Cancer—A Prospective Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To analyse sex differences in health‐related quality of life (HRQL) before, during and up to 3 months posttreatment of head and neck cancer, and to examine the importance of salivary secretion rate for HRQL posttreatment. Methods Patients were recruited before starting curative oncologic treatment.
Niklas Bohm, Charlott Karlsson, Caterina Finizia, Jessica Skoogh Andersson, Annica Almståhl   +4 more
wiley   +1 more source

The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial. [PDF]

Nutrients, 2022
Babina K, Salikhova D, Polyakova M, Svitich O, Samoylikov R, Ahmad El-Abed S, Zaytsev A, Novozhilova N.   +7 more
europepmc   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, EarlyView.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source