Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening
Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE/Ag‐ or phorbol 12‐myristate 13‐acetate (PMA)/ionomycin‐mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new
Shiori Mamorita +3 more
wiley +1 more source
Impact of Secretory Immunoglobulin A Level on Dental Caries Experience in Asthmatic Children. [PDF]
Arafa A, AlDahlawi S, Hussien A.
europepmc +1 more source
Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu +4 more
wiley +1 more source
Clinical Analysis of Neonatal Influenza in the Neonatal Intensive Care Unit: A Retrospective Study
ABSTRACT Background To describe the clinical characteristics, treatment, and outcomes of neonatal influenza. Methods Retrospectively analyzed clinical data on 26 neonates who were diagnosed with neonatal influenza by positive influenza nasopharyngeal swab antigen tests, and admitted to the neonatal intensive care unit of Sichuan Province Chengdu ...
Min Zhou +5 more
wiley +1 more source
Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis. [PDF]
Carsetti R +15 more
europepmc +1 more source
Secretory immunoglobulin A and intestinal diseases
Bo Han +5 more
openaire +1 more source
ABSTRACT Small extracellular vesicles (sEVs) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity; however, their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potential of CTL‐derived exosomes.
Nadia Alawar +10 more
wiley +1 more source
Transformation strategies for stable expression of complex hetero-multimeric proteins like secretory immunoglobulin A in plants. [PDF]
Palaci J, Virdi V, Depicker A.
europepmc +1 more source
Prenatal and postnatal cigarette and cannabis exposure: Effects on Secretory Immunoglobulin A in early childhood. [PDF]
Molnar DS +3 more
europepmc +1 more source
Abstract To describe the clinical scenario and need for longitudinal follow‐up of pediatric patients presenting with esophageal food impactions (EFIs) regardless of esophageal biopsy eosinophil count. A retrospective chart review was conducted on patients with EFI who underwent endoscopic evaluation from August 2022 to August 2024.
Mark Mahon, Amanda Muir
wiley +1 more source

