Results 121 to 130 of about 17,164,709 (325)
Evaluation of mainline aircraft center section weight efficiency
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроениеA method for evaluating the mainline aircraft center section weight efficiency based on a mathematical model of a deformable solid body of variable density was developed.
A. V. Boldyrev, D. V. Zolotov
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
An Analysis of Deixis in “Beauty and The Beast” Movie Script
Journal of English Education and TeachingDeixis has an important role to build the communication process. This research aimed to find out the distribution of scenes, types of deixis are often found and distribution of deixis in all sections of Beauty and The Beast movie script by using Cruse ...
Oktazsya Marjelina Lorenza +2 more
doaj +1 more source
Antipollution system to remove nitrogen dioxide gas [PDF]
, 1971 Gas phase reaction system using anhydrous ammonia removes nitrogen dioxide. System consists of ammonia injection and mixing section, reaction section /reactor/, and scrubber section.
Metzler, A. J., Slough, J. W.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Social Dialogue for Decent Work [PDF]
, 2006 [Excerpt] This paper aims to develop usable indicators of the concept of social dialogue, as part of the ILO\u27s effort to develop operational measures of Decent Work. Section 1 examines the concept of social dialogue. Section 2 looks at past approaches
Kuruvilla, Sarosh
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source