Results 61 to 70 of about 14,239,838 (283)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Section Chern number for a 3D photonic crystal and the bulk-edge correspondence

, 2016
We have characterized the robust propagation modes of electromagnetic waves in helical structures by the section Chern number that is defined for a two-dimensional (2D) section of the three- dimensional (3D) Brillouin zone. The Weyl point in the photonic
Hatsugai, Yasuhiro, Kariyado, Toshikaze, Oono, Shuhei   +2 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Re-Coopering anti-psychiatry: David Cooper, revolutionary critic of psychiatry [PDF]

, 2016
This article offers an introduction to David Cooper (1931–86), who coined the term ‘anti-psychiatry’, and, it is argued here, has not so far received the scholarly attention that he deserves. The first section presents his life in context.
Chapman, Adrian
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

SOCIO-PSYCHOLOGICAL ASPECTS OF A TEENAGER'S PERSONAL DEVELOPMENT IN THE EDUCATIONAL ENVIRONMENT OF PRE-EDUCATION

Russian Journal of Education and Psychology
Background. In the context of the development of informatization of society and the availability of diverse information on the Internet, adolescents have a great opportunity to expand beyond the educational institution.
Aleksey V. Basov
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Automated Layer-by-Layer Soil Tillage Machine Using a Highly Turbulent Air Jet

Сельскохозяйственные машины и технологии
The paper highlights that preserving and enhancing the soil fertility of agricultural lands remains one of the most pressing challenges for the national economy.
B. Kh. Akhalaya, Yu. S. Tsench, N. I. Belyaeva   +2 more
doaj   +1 more source

Flexible thermal apparatus for mounting of thermoelectric cooler [PDF]

, 1991
A flexible heat transfer apparatus used to flexibly connect and thermally couple a thermoelectric cooler to an object to be cooled is disclosed. The flexible heat transfer apparatus consists of a pair of flexible corrugated sheets made from high thermal ...
Bard, Steven, Jones, Jack A., Petrick, S. Walter   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source