Results 71 to 80 of about 2,710,674 (198)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The Potsdam Soil Moisture Observatory: high-coverage reference observations at kilometer scale [PDF]

Earth System Science Data
Cosmic-ray neutron sensing (CRNS) has gained popularity for estimating soil moisture due to its innovative capability to measure at an intermediate scale – a notable advantage over point-scale sensors, which are often sparsely installed and lead to ...
P. M. Grosse, P. M. Grosse, E. Marret, L. Scheiffele, L. Scheiffele, K. Dimitrova Petrova, T. Francke, D. Altdorff, D. Altdorff, M. Heistermann, M. Schiel, C. Neumann, D. Scheffler, M. Saberioon, M. Kunz, J. Marach, M. Reginatto, M. Zboril, A. Balenzano, D. Rasche, C. Stumpp, B. Trost, S. E. Oswald   +22 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Non-compulsory care for children and young people: learning from research on Section 25 arrangements. What next for Scotland?

Scottish Journal of Residential Child Care
This paper presents the key issues arising for social work practice from a 30-month mixed-methods study on how Section 25 of the Children (Scotland) Act 1995 was used, understood and experienced.
Brandi Lee Lough Dennell, Robert B. Porter, Micky Anderson   +2 more
doaj   +1 more source

Trends in maternal body mass index, macrosomia and caesarean section in first-time mothers during the pandemic: a multicentre retrospective cohort study of 12 Melbourne public hospitals

BMC Pregnancy and Childbirth
Objective To compare specific perinatal outcomes in nulliparas with a singleton infant in cephalic presentation at term, with and without exposure to the COVID-19 pandemic during pregnancy.
Andrew J. Goldsack, Melvin B. Marzan, Daniel L. Rolnik, Anthea C. Lindquist, Joanne M. Said, Kirsten R. Palmer, Penelope M. Sheehan, Stephanie Potenza, Natasha Pritchard, Clare L. Whitehead, Jolyon Ford, Ben W. Mol, Susan P. Walker, Lisa Hui   +13 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Housing and health: A multidimensional, qualitative analysis of the experiences of asylum seekers and refugees living in German reception centres

SSM: Qualitative Research in Health
Objectives: Housing is an important social determinant of health, but the perspectives of asylum seekers and refugees (ASR) in large, centralised reception centres remain under-researched. We therefore sought to examine which housing aspects in reception
Eilin Rast, Maren Hintermeier, Kayvan Bozorgmehr, Louise Biddle   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source