Results 141 to 150 of about 1,746,741 (337)
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
On non-Riemannian sectional curvature in Riemannian homogeneous spaces [PDF]
, 1971 Isaac Chavel
openalex +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Lorentzian Beltrami-Euler formula and generalized Lorentzian Lamarle formila in R_1^n
Le Matematiche, 2009 In this paper, the sectional curvature of non-degenerate tangent sections of time-like ruled surface with the central ruled surface in n-dimensional Minkowski space, R_1^n is studied. The relationship between normal sectional curvature and the principal
Soley Ersoy, Murat Tosun
doaj
On totally umbilical CR-submanifolds of a Kaehler manifold
International Journal of Mathematics and Mathematical Sciences, 1993 Let M be a compact 3-dimensional totally umbilical CR-submanifold of a Kaehler manifold of positive holomorphic sectional curvature. We prove that if the length of the mean curvature vector of M does not vanish, then M is either diffeomorphic to S3 or ...
M. A. Bashir
doaj +1 more source
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
Positive sectional curvatures does not imply positive Gauss-Bonnet integrand [PDF]
, 1976 Robert Geroch
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Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Homogeneous convex domains of negative sectional curvature [PDF]
, 1977 Hirohiko Shima
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FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source