Results 101 to 110 of about 2,562,861 (296)
, 2016 We apply high-level ab initio methods to describe the electronic structure of small clusters of ammonia and dimethyl ether (DME) doped with sodium, which provide a model for solvated electrons. We investigate the effect of the solvent and cluster size on
Anastasia O. Gunina (1235790) +1 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Gut MicrobesMetabolic endotoxemia is an important risk factor for the metabolic syndrome (MetS). We report that lipopolysaccharides (LPS) are transcellularly transported from the jejunal lumen during long-chain fatty acids (LCFA) absorption via caveolin (Cav)-1 ...
Yasutada Akiba +2 more
doaj +1 more source
Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells
Journal of Lipid Research, 2015 Two APOL1 gene variants, which likely evolved to protect individuals from African sleeping sickness, are strongly associated with nondiabetic kidney disease in individuals with recent African ancestry. Consistent with its role in trypanosome killing, the
Dongmei Cheng +8 more
doaj +1 more source
Measurement of the multi-jet cross-sections with the ATLAS detector at the LHC
, 2012 Inclusive multi-jet production is studied using the ATLAS detector for proton-proton collisions with a center-of-mass energy of 7 TeV at the Large Hadron Collider at CERN.
ZINONOS, ZINONAS
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
RNA from fresh frozen cryosections of oil palm inflorescences is superior to FFPE sections [PDF]
, 2016 Formalin-fixed, paraffin-embedded (FFPE) and fresh frozen (FF) tissue sections are valuable sources for histology and molecular studies. However, FFPE tissue sections usually provide poor quality RNA that is unsuitable for most downstream molecular ...
Abdullah, Meilina Ong +5 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
Nature Communications, 2019 Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid ...
Masaji Sakaguchi +15 more
doaj +1 more source