Results 71 to 80 of about 2,562,861 (296)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The serum-based VeriStrat® test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients

BMC Cancer, 2018
Background The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemotherapy in previously treated ...
Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A. Borgia   +9 more
doaj   +1 more source

Differential cross sections for electron impact excitation of then= 2 states of helium at intermediate energies (80, 100 and 120 eV) measured across the complete angular scattering range (0–180°) [PDF]

, 2011
Differential cross sections (DCS) for inelastic electron scattering to the n = 2 states in helium have been measured at incident energies of 80, 100 and 120 eV.
Read, F., O Zatsarinny, F H Read, King, G C, Ward, R., Bartschat, K., N Bowring, Zatsarinny, O, Bartschat, K, D Cubric, K Bartschat, Read, F H, G C King, D V Fursa, Bray, I, Cubric, D, Bowring, N., King, G., I Bray, Ward, Rupert, R Ward, Bowring, N, Cubric, D., Zatsarinny, O., Fursa, D V, Bray, Igor, Ward, R, Fursa, Dmitry   +27 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Rhythm requires poetic sections

, 2016
This is a proposed as an absolute (implicational) universal, and comes from Fabb and Halle (Meter): Where a text has a sustained regular rhythm, it is also divided into sections of determinate length.
Fabb, Nigel
core  

Roles of Pathological Assessments of Frozen Sections in Esophageal Squamous Cell Carcinoma

, 2020
Pathological assessment of frozen sections of tissues is important in the clinical management (intraoperative consultation) and research in patients with esophageal squamous cell carcinoma.
Lam, AK, Alfred K. Lam
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Mycobacterial Brain Tuberculomas due to Bacille Calmette-Guérin Intravesical Chemotherapy for Bladder Cancer: A Case Report and Literature Review

Canadian Journal of Infectious Diseases and Medical Microbiology, 2011
Bacille Calmette-Guérin (BCG) immunotherapy is widely used for the treatment of superficial bladder cancer. The authors believe that the present report is one of the first to document cerebral BCG tuberculoma in a 73-year-old immunocompetent man, three ...
Vitaly Golub, Prashant Malhotra, Shital Patel   +2 more
doaj   +1 more source

Recent innovations in cold-formed tubular sections

, 1998
Cold-formed tubular sections are widely used in many modern steel structures. Two innovative cold-formed sections have been introduced to the Australian building industry.
Zhao, X. L., X.L Zhao, Mahendran, M., M Mahendran   +3 more
core   +1 more source