Results 51 to 60 of about 460,990 (261)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Secure generalized deduplication via multi-key revealing encryption [PDF]

, 2020
Cloud Storage Providers (CSPs) offer solutions to relieve users from locally storing vast amounts of data, including personal and sensitive ones. While users may desire to retain some privacy on the data they outsource, CSPs are interested in reducing ...
Lars Nielsen, Rasmus Vestergaard, Orlandi, Claudio, Pagnin, Elena, Daniel E. Lucani, Claudio Orlandi, Lucani, Daniel E., Nielsen, Lars, Vestergaard, Rasmus, Daniel E. Lucani, Elena Pagnin   +10 more
core   +2 more sources

SDVADC: Secure Deduplication and Virtual Auditing of Data in Cloud [PDF]

, 2020
Over the last few years, deploying data to cloud service for repository is an appealing passion that avoids efforts on significant information sustenance and administration.
Iyengar, SS, Buyya, R, Geetaa, C.M., Raghavendra, S., Shreyas Raju, RG, jkumar Buyya, ., Iyengar, S.S., Geeta, CM, Raghavendra, S, Shreyas Raju, R.G., Venugopal, KR, Patnaik, LM, Venugopal, K.R., Patnaik, L.M.   +13 more
core   +2 more sources

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

A novel approach to data integrity auditing in PCS: Minimising any Trust on Third Parties (DIA-MTTP).

PLoS ONE, 2021
Data Integrity Auditing (DIA) is a security service for verifying the integrity of outsourced data in Public Cloud Storage (PCS) by users or by Third-Party Auditors (TPAs) on behalf of the users. This paper proposes a novel DIA framework, called DIA-MTTP.
Reem Almarwani, Ning Zhang, James Garside   +2 more
doaj   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

DEDUCT: A Secure Deduplication of Textual Data in Cloud Environments

IEEE Access
The exponential growth of textual data in Vision-and-Language Navigation tasks poses significant challenges for data management in large-scale storage systems.
Kiana Ghassabi, Peyman Pahlevani
doaj   +1 more source

A HYBRID CLOUD APPROACH FOR SECURE APPROVED DEDUPLICATION [PDF]

, 2016
Information Deduplication is one of imperative information pressure systems for wiping out copy duplicates of rehashing information, and has been generally utilized as a part of distributed storage to decrease the measure of storage room and spare data ...
Abhinandan K*, Prasanna Kumar M
core   +1 more source