Results 51 to 60 of about 3,620,659 (295)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Developer-oriented Web Security by Integrating Secure SDLC into IDEs
Sakarya University Journal of Computer and Information Sciences, 2018 Enterprises and organizations have difficulties to protect their web-based services against cyber-attacks. Due to increasing number of cyber-attacks, critical data including customer data, patient data etc.
Emin İslam Tatlı
doaj
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Software engineering best practices for developing secure and reliable applications [PDF]
, 2023 This paper discusses software engineering best practices for developing secure and reliable applications. Presenting a comprehensive overview of the software development process and discuss the importance of incorporating security and reliability into ...
PRODIUS, Cristian
core +1 more source
How Can Secure Software be Trusted?
South African Computer Journal, 2011 The security of software applications is a major concern, especially for information owners, software developers and users. Increasingly, these stakeholders need to be confident that the software applications being developed are secure and can be trusted
Lynn Futcher, Rossouw Von Solms
doaj
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
A Factory-based Approach to Support E-commerce Agent Fabrication [PDF]
, 2004 With the development of Internet computing and software agent technologies, agent-based e-commerce is emerging. How to create agents for e-commerce applications has become an important issue along the way to success.
Maung, MT +5 more
core +1 more source
, 2023 This slide deck provides a concise yet comprehensive overview of commonly used software development models, ranging from the traditional waterfall to the more advanced NIST secure software development model.
Nitin Sukhija
core +1 more source