Results 61 to 70 of about 18,222,506 (296)

Secure software development practice selection model [PDF]

open access: yes, 2020
Developing secure software is critical for organizations as highly-sensitive and confidential data are transacted through online applications. Insecure software can lead to loss of revenue and damage to business reputation.
Kanniah, Sri Lakshmi
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

Web development evolution: the business perspective on security [PDF]

open access: yes, 2006
Protection of data, information, and knowledge is a hot topic in today’s business environment. Societal, legislative and consumer pressures are forcing companies to examine business strategies, modify processes and acknowledge security to accept and ...
Glisson, L.M.   +2 more
core   +5 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Software engineering best practices for developing secure and reliable applications [PDF]

open access: yes, 2023
This paper discusses software engineering best practices for developing secure and reliable applications. Presenting a comprehensive overview of the software development process and discuss the importance of incorporating security and reliability into ...
PRODIUS, Cristian
core   +1 more source

Software Development Initiatives to Identify and Mitigate Security Threats - Two Systematic Mapping Studies

open access: yesCLEI Electronic Journal, 2016
Software Security and development experts have addressed the problem of building secure software systems. There are several processes and initiatives to achieve secure software systems.
Paulina Silva   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Automating Risk Analysis of Software Design Models

open access: yesThe Scientific World Journal, 2014
The growth of the internet and networked systems has exposed software to an increased amount of security threats. One of the responses from software developers to these threats is the introduction of security activities in the software development ...
Maxime Frydman   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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