Results 41 to 50 of about 1,953,986 (295)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Position and treatment of convicts with mental disorders in penal system [PDF]
Specijalna Edukacija i Rehabilitacija, 2019 Persons with mental illnesses may be deprived of their freedom should they be associated with committing crime. Te rate of convicts with mental disorders in prisons ranges between 15% and 25%.
Milošević Slađana +2 more
doaj
Temporary access to things and documents: problematic issues of law enforcement
Проблеми Законності, 2020 The article explores the issues of the victim's involvement in the process of obtaining temporary access to things and documents. The current legislative provisions were analyzed, according to it only the parties to criminal proceedings have the right to
Марина Игоревна Демура +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Measuring Social Security's Financial Problems [PDF]
SSRN Electronic Journal, 2005 The U.S. Social Security system has helped keep many retirees out of poverty. However, according to the Social Security and Medicare Trustees, Social Security faces a future financial shortfall of $10.4 trillion in present value. This enormous imbalance has received little attention in public debates about Social Security.
Jagadeesh Gokhale, Kent Smetters
openaire +2 more sources
New Zealand regions, 1986-2001: Dependency and development of social capital [PDF]
, 2006 The development of social capital is significantly affected by benefit dependency of the population. This paper investigates measures of social cohesion and measures of dependency on society across the regions of New Zealand.
Baxendine, Sandra +3 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Nursing ReportsBackground/Objectives: The use of coercive measures (CMs) and security technologies (STs) in mental healthcare continues to raise ethical and practical concerns, affecting both patient and staff well-being.
Giuliano Anastasi +4 more
doaj +1 more source
European Journal of Investigation in Health, Psychology and Education, 2021 The COVID-19 pandemic caused the start of the academic year 2020/2021 to be conditioned by health and safety regulations. The present research was defined with the aim of analyzing the degree of satisfaction and perceptions on the establishment of bubble
Óscar Rodríguez-Nogueira +4 more
doaj +1 more source