Results 51 to 60 of about 160,482 (313)
Energy Science & EngineeringThe challenge of providing water, energy, food, and managing the environment (WEFEN) is widely recognized as a significant barrier to global advancement in light of the increasing population.
Rahim Zahedi +4 more
doaj +1 more source
Rethinking the security of the European Union’s gas supply. Bruegel Policy Contribution, Issue 2016/01 January 2016 [PDF]
, 2016 Highlights: • The security of the European Union’s gas supplies is crucial to ensuring that supplies to households are not disrupted in freezing winters, that industry can flourish and that the EU cannot be blackmailed in vital foreign policy ...
Tagliapietra, Simone, Zachmann, Georg.
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Occurrence and ecological risk of typical pesticides in a river–lake system
Water Science and EngineeringPesticides are widely used in agriculture and can enter river–lake systems through surface runoff, adversely affecting non-target organisms and threatening ecological security. This study investigated the occurrence and distribution of 52 pesticides in a
Yi-hao Qin +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Journal of Modern ScienceObjectives The aim of the article was to analyze and evaluate logistics processes on the example of selected organizations in terms of the risk of implementing sustainable development in the supply chain.
Dorota Krupnik, Monika Szczerbak
doaj +1 more source
Urban food security at the intersection of retail supply chain management and development studies
, 2021 This thesis examines urban food security at the intersection of retail supply chain management and development studies. Food security in a multifaceted issue and has previously been framed through agricultural production and the fundamental availability ...
Tuomala, Virva
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Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source