Results 31 to 40 of about 5,469 (211)

Addressing the Paradox: Counterinsurgency, Human Rights and Women in Northeast Nigeria

open access: yesAge of Human Rights Journal, 2020
Counterinsurgency (COIN) operations often result in widespread human rights violations because COIN operations are usually premised on the erroneous assumption of irreconcilable tension between human rights and national security. By reviewing narratives
David Ibukun
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

PROVISIONS REFORMULATION FOR THE RESPONSIBILITY OF HUMAN RIGHTS FULFILLMENT

open access: yesJournal of Social Sciences, 2023
Fulfillment of human rights, especially social security rights based on the 1945 Constitution of the Republic of Indonesia, still does not show justice for all Indonesian citizens.
HERMAWANTO   +3 more
doaj   +1 more source

Security in Rights as a Variety of National Security

open access: yesCuestiones Políticas, 2020
Study purpose is to determine the signs of legal security on the basis of existing scientific views and current legislation, excluding its overly broad understanding, leading to the fact that any legal requirement is included in the content of national security.
Guzel Anvarovna Valeeva   +2 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

ECONOMIC SECURITY OF THE INDIVIDUAL AS A COMPONENT OF THE FIFTH GENERATION HUMAN RIGHTS CONCEPT

open access: yesBaltic Journal of Economic Studies
The contemporary world is characterised by an escalation in military conflicts and political and economic instability, which have a substantial impact on the economic security of the individual.
Ivan Shved, Mykola Kotsur, Vasyl Chornei
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

The Crisis of Security of an Individual in the European Union in the Context of Refugee Rights

open access: yesStudia Iuridica Lublinensia, 2019
Globally, it is worth stressing that international law, European law and national laws must fulfill the same standards, considering the human rights laws.
Wojciech Konaszczuk
doaj   +1 more source

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