Results 41 to 50 of about 242,778 (310)

The design of a multicentre Canadian surveillance study of sedation safety in the paediatric emergency department

, 2015
Procedural sedation and analgesia have become standard practice in paediatric emergency departments worldwide. Although generally regarded as safe, serious adverse events such as bradycardia, asystole, pulmonary aspiration, permanent neurological injury ...
Beno, Suzanne, Dixon, Andrew, Roback, Mark. G, Johnson, David W., Joubert, Gary, Barrowman, Nick, McTimoney, C. Michelle, Bhatt, Maala, Ali, Samina, Dubrovsky, Alexander Sasha, Farion, Ken J.   +10 more
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Sedation protocols to reduce duration of mechanical ventilation in the ICU: a Cochrane Systematic Review [PDF]

, 2016
Aims: Assess the effects of protocol-directed sedation management on the duration of mechanical ventilation and other relevant patient outcomes in mechanically ventilated intensive care unit patients.
Bucknall, T, Burmeister, E, Aitken, L. M., Aitken, Leanne M., Burmeister, Elizabeth, Mitchell, M., Bucknall, T.K., Keogh, S. J., Aitken, LM, Aitken, Leanne M, Mitchell, Marion, Kent, Bridie, Mitchell, M, Burmeister, E., Kent, B., Keogh, Samantha, Keogh, S, Kent, B, Bucknall, Tracey   +18 more
core   +2 more sources

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Sedation in Europe [PDF]

British Dental Journal, 2008
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ZANETTE, GASTONE, FACCO, ENRICO, MANANI G.   +2 more
openaire   +2 more sources

Pediatric Sedation: The Asian Approach - Current State of Sedation in China

, 2015
In China, the need for sedation and analgesia for both diagnostic and therapeutic procedures performed outside the operating room has increased dramatically in recent years.
Yuen, VMY, Xu, Y, Li, BL, Wang Ning, SG, Chen, X, Wang, C, Irwin, MG   +6 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Palliative sedation in amyotrophic lateral sclerosis: results of a nationwide survey among neurologists and palliative care practitioners in Germany

BMC Neurology, 2022
Background Palliative sedation has become widely accepted as a method to alleviate refractory symptoms in terminally ill patients. Controversies regarding this topic especially concern the use of palliative sedation for psychological symptoms, the use in
Laura Salzmann, Bernd Alt-Epping, Alfred Simon   +2 more
doaj   +1 more source

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

, 2012
CONTEXT: Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort.
Garrat, C, Dexmedetomidine for long term sedation investigators,, Grounds, RM, Sarapohja, T, Ruokonen, Esko, Takala, Jukka, Sarapohja, Toni, Pocock, Stuart J, Ruokonen, E, Jakob, SM, Grounds, R Michael, Pocock, SJ, Garratt, Chris, Bratty, J Raymond, Dexmedetomidine for Long-Term Sedation Investigators, Jakob, Stephan M, Bratty, JR, Takala, J, LAMBERMONT, Bernard, Dexmedetomidine for Long-Term Sedation, Investigators, Jakob, Stephan, Jakob SM, Garratt C, Sarapohja T, Grounds RM, Bratty JR, Pocock SJ, Ruokonen E, Takala J   +28 more
core   +1 more source