Results 121 to 130 of about 68,488 (302)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Comparision of the ramsey sedation scale with bispectral i·ndex monitoring in the patients undergoing ercp for sedation application [PDF]
, 2013 Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır.Yayınlanma izni olmayan tezlerin basılı kopyalarına üniversite kütüphaneniz aracılığı ile (TÜBESS üzerinden) erişebilirsiniz.Bu çalışmada; ERCP sırasında profolle uygulanan sedasyon ...
Polat, Nagihan
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The effects of BIS monitoring on sedation in intensive care units [PDF]
Introduction. Sedation in intensive care units (ICUs) is crucial, especially for patients on mechanical ventilation. Deep sedation is associated with longer ICU stays and more days on mechanical ventilation. Aim.
Platikanov, Vilian Hristov; Department of Anesthesiology, Emergency and Intensive Medicine, Medical University of Varna +1 more
core +2 more sources
Pakistan Journal of Pharmaceutical SciencesObjectives: To compare the impact of titrated versus fixed-dose remifentanil infusion on hemodynamic variability, sedation quality, and peri-procedural complications in elderly patients undergoing elective bronchoscopy.
Yunfeng Zhang, Xinglu Xia
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The addition of capnography to standard monitoring reduces hypoxemic events during gastrointestinal endoscopic sedation: a systematic review and meta-analysis [PDF]
, 2018 Seung Hyun Kim,1 Minsu Park,2 Jinae Lee,2 Eungjin Kim,1 Yong Seon Choi3 1Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; 2Biostatistics Collaboration Unit, Yonsei University ...
Kim SH, Kim EJ, Park M, Lee J, Choi YS
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Bispectral index compared to Ramsay score for sedation monitoring in intensive care units [PDF]
, 2006 Aim. Continuous monitoring is of paramount importance in order to obtain a correct level of sedation in ICU patients. Clinical scoring systems, although simple and inexpensive, are often inadequate in evaluating the patient level of consciousness.
Consales G. +3 more
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