Results 51 to 60 of about 73,143 (255)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Monitoring of sedation, analgesia and delirium with validated scores.

, 2014
Mosaic plot: The areas of the mosaic tiles are proportional to the observed frequency of groups. Both, sedation and pain monitoring. None, no sedation and no pain monitoring.
Felix Balzer (295591), Klaus-Dieter Wernecke (34400), Christina Jones (660931), Giuseppe Citerio (660932), Bjoern Weiss (660933), Finn M. Radtke (660930), Claudia Spies (11807), Alawi Luetz (660929), Bernhard Walder (548930)   +8 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Sedation and Hemodynamics

, 2017
In critically ill patients, several pathological conditions could impair hemodynamic function. However, even iatrogenic factors like sedative drugs, commonly administered to ensure comfort to patients, may contribute to deteriorate oxygen delivery (DO2 ...
Sabino Scolletta, Loredana Mazzetti, Scolletta S., Franchi F., Federico Franchi, Mazzetti L.   +5 more
core   +1 more source

Avaliação das alterações da saturação periférica de oxigênio, da tensão arterial e do pulso em pacientes submetidos à sedação consciente para endoscopia digestiva alta [PDF]

, 2009
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Kauling, Ana Laura Colle
core  

Comparison Between Dexmedetomidine and Propofol with Validation of Bispectral Index For Sedation in Mechanically Ventilated Intensive Care Patients [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background and Aim: Sedation plays a pivotal role in the care of the critically ill patient. It is equally important to assess depth of sedation. The present study had been designed to compare dexmedetomidine and propofol for sedation in mechanically
BHARAT PALIWAL, PYUSH RAI, MANOJ KAMAL, GEETA SINGARIYA, MADHU SINGHAL, PRIYANKA GUPTA, TANUJA TRIVEDI, DILIP SINGH CHOUHAN   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Auditory evoked potential wave VI as an objective indicator of sedation depth in neonates undergoing chloral hydrate sedation: a double-blind randomized controlled study

Frontiers in Pediatrics
BackgroundNeonatal sedation depth monitoring is critical yet depends on the subjective Ramsay scale when used and lacks objective biomarkers. Although auditory evoked potential (AEP) wave VI disappearance is linked to reduced consciousness, its use for ...
Zong Zheng, Shanpu Yang, Hongyan Liu, Zhimin Sheng   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source