Results 51 to 60 of about 68,013 (302)

Sedation and Hemodynamics

, 2017
In critically ill patients, several pathological conditions could impair hemodynamic function. However, even iatrogenic factors like sedative drugs, commonly administered to ensure comfort to patients, may contribute to deteriorate oxygen delivery (DO2 ...
Sabino Scolletta, Loredana Mazzetti, Scolletta S., Franchi F., Federico Franchi, Mazzetti L.   +5 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Monitoring sedation in the critically ill child [PDF]

Anaesthesia, 2010
Summary Sedation is an essential part of the management of the critically ill child, and its monitoring must be individualised and continuous in order to adjust drug doses according to the clinical state. There is no ideal method for evaluating sedation in the critically ill child.
A, Lamas, Jesús, López-Herce
openaire   +2 more sources

Monitoring of sedation, analgesia and delirium with validated scores.

, 2014
Mosaic plot: The areas of the mosaic tiles are proportional to the observed frequency of groups. Both, sedation and pain monitoring. None, no sedation and no pain monitoring.
Felix Balzer (295591), Klaus-Dieter Wernecke (34400), Christina Jones (660931), Giuseppe Citerio (660932), Bjoern Weiss (660933), Finn M. Radtke (660930), Claudia Spies (11807), Alawi Luetz (660929), Bernhard Walder (548930)   +8 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Auditory evoked potential wave VI as an objective indicator of sedation depth in neonates undergoing chloral hydrate sedation: a double-blind randomized controlled study

Frontiers in Pediatrics
BackgroundNeonatal sedation depth monitoring is critical yet depends on the subjective Ramsay scale when used and lacks objective biomarkers. Although auditory evoked potential (AEP) wave VI disappearance is linked to reduced consciousness, its use for ...
Zong Zheng, Shanpu Yang, Hongyan Liu, Zhimin Sheng   +3 more
doaj   +1 more source

Capnography and the Bispectral Index—Their Role in Pediatric Sedation: A Brief Review

International Journal of Pediatrics, 2010
Sedation in children is increasingly emerging as a minimally invasive technique that may be associated with local anaesthesia or diagnostic and therapeutic procedures which do not necessarily require general anaesthesia.
Maria Sammartino, Barbara Volpe, Fabio Sbaraglia, Rossella Garra, Alessandro D'Addessi   +4 more
doaj   +1 more source

Avaliação das alterações da saturação periférica de oxigênio, da tensão arterial e do pulso em pacientes submetidos à sedação consciente para endoscopia digestiva alta [PDF]

, 2009
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Kauling, Ana Laura Colle
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Journal of Intensive Care, 2018
Background Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importance.
Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek, Guido Michels   +9 more
doaj   +1 more source