Results 81 to 90 of about 73,143 (255)

Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation [PDF]

, 2016
BackgroundDiagnostic and interventional procedures are often facilitated by moderate procedure-related sedation. Many studies support the overall safety of this sedation; however, adverse cardiovascular and respiratory events are reported in up to 70% of
Lenart, John, Meineke, Minhthy N, Hassanian, Mohammad, Um, Michael, Applegate, Richard L, Kruger, Alison, Ching, Jeffrey, Qoshlli, Silvana, Malkin, Mathew, Neumann, Monica, Jacobson, J Paul   +10 more
core   +1 more source

Functional near-infrared spectroscopy assessment of the brain functional connectivity of sedated patients in the emergency intensive care unit

Scientific Reports
Sedation during mechanical ventilation is common in intensive care units (ICUs). Functional near-infrared spectroscopy (fNIRS) has shown potential in monitoring brain function.
Haotian Lu, Anke Shi, Jieqiong Yu, Jing Zhao, Mingshuai Ai, Guoqiang Zhang, Shengtao Yan   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pediatric dental sedation: challenges and opportunities

, 2015
Travis M Nelson, Zheng Xu Department of Pediatric Dentistry, University of Washington, Seattle, WA, USA Abstract: High levels of dental caries, challenging child behavior, and parent expectations support a need for sedation in pediatric dentistry.
Nelson TM, Xu Z
core  

Sedation management and processed EEG-based solutions during venovenous extracorporeal membrane oxygenation: a narrative review of key challenges and potential benefits. [PDF]

Extracorporeal membrane oxygenation (ECMO) is an established technique for managing severe cardiorespiratory failure. However, it is invasive and requires profound analgo-sedation during initiation and often throughout the therapy.
Bibleraaj, Bhuvana, Szentgyorgyi, Lajos, Howitt, Samuel Henry, Iles-Smith, Heather   +3 more
core   +1 more source

Sedation in the intensive care unit (ICU) and procedural sedation: clinical guidelines and personal practice

Медицина болю
The presented literature review describes key issues of sedation in ICU patients and procedural sedation during medical examinations and manipulations. Attention is paid to issues of monitoring the depth of sedation and vital functions to ensure patient
O Budniuk, I Yovenko, D Havrychenko
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Korean clinical practice guidelines for diagnostic and procedural sedation [PDF]

Korean Journal of Anesthesiology
Safe and effective sedation depends on various factors, such as the choice of sedatives, sedation techniques used, experience of the sedation provider, degree of sedation-related education and training, equipment and healthcare worker availability, the ...
Sang-Hyun Kim, Young-Jin Moon, Min Suk Chae, Yea-Ji Lee, Myong-Hwan Karm, Eun-Young Joo, Jeong-Jin Min, Bon-Nyeo Koo, Jeong-Hyun Choi, Jin-Young Hwang, Yeonmi Yang, Min A Kwon, Hyun Jung Koh, Jong Yeop Kim, Sun Young Park, Hyunjee Kim, Yang-Hoon Chung, Na Young Kim, Sung Uk Choi   +18 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source