Results 51 to 60 of about 93,220 (267)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Joint association of antioxidant intakes from diet and supplements and sedentary behavior with all-cause and cardiovascular disease mortality among US adults

BMC Public Health
Background Imbalanced dietary patterns, sedentary behavior, and other unhealthy lifestyle behaviors are among the potentially modifiable risk factors most consistently linked to all-cause and cardiovascular disease (CVD) mortality.
Dingyuan Tu, Zhiqiang Song, Changzhen Ren, Yuhong Hu, Qun Jin, Yang Wang   +5 more
doaj   +1 more source

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

Social-ecological correlates of accelerometer-measured occupational sitting among Japanese desk-based workers

BMC Public Health, 2019
Background Although the main targets for reducing workplace sedentary behavior have been clarified, only a few studies have examined the association between social-ecological factors and workplace sedentary behavior for effective intervention.
Satoshi Kurita, Ai Shibata, Kaori Ishii, Mohammad Javad Koohsari, Koichiro Oka   +4 more
doaj   +1 more source

The Effect of Resistance Training and Ursolic Acid on the PI3K‐AKT‐mTOR Pathway in Aged Diabetic Rats: A Comparative Study

AGING MEDICINE, EarlyView.
Resistance training combined with ursolic acid supplementation restores anabolic signaling (PI3K/mTORC1) suppressed by diabetes, helping preserve muscle mass. This strategy may offer a potential therapeutic approach to combat muscle atrophy and support healthy aging in diabetic conditions.
Ashkan Sadeghi, Safoura Alizade, Mohammad Faramarzi, Mostafa Rahimi, Rohit Kumar Thapa   +4 more
wiley   +1 more source

Determining the Protective Effects of Long‐Term Physical Activity, Exercise, Mental Health, and Employment on Sarcopenia—A Result of a Feasibility Study of a Registry

AGING MEDICINE, EarlyView.
This study highlights that physical activity, employment, and mental health significantly influence sarcopenia risk in healthy adults. Working part‐time or full‐time and exercising, especially sports like swimming, alongside good psychological health, may be associated with reduced odds of sarcopenia.
Mohammad Reza Shadmand Foumani Moghadam, Mostafa Shahraki Jazinaki, Sharif Etemadi, Kazem Eslami, Pegah Meghdadi, Parnian Pezeshki, Mohammad Amoushahi, Reyhane Bakhshipour, Majid Ghayour Mobarhan, Majid Khadem‐Rezaiyan, Reza Rezvani, Zohre Hosseini   +11 more
wiley   +1 more source

Combined effects of physical activity and sedentary behavior on all-cause mortality in heart failure patients: A cohort study of national health and nutrition examination survey analysis

Frontiers in Cardiovascular Medicine, 2022
BackgroundPhysical activity and sedentary behavior are independently related to the risk of cardiovascular disease. Physical activity is recognized as having a protective effect, while being sedentary seems to be adverse.
Yunhui Zhu, Zhebin Chen, Songzan Chen, Guosheng Fu, Yao Wang   +4 more
doaj   +1 more source

Morbidity Among the Aging Population in Northern Bangladesh: An Epidemiological Study

AGING MEDICINE, EarlyView.
Multimorbidity (≥ 2 chronic diseases) is common among aging populations, yet evidence from Bangladesh remains limited. A cross‐sectional survey of 540 older adults in Northern Bangladesh (June–August 2022) assessed multimorbidity using interviews and logistic regression analysis. Multimorbidity prevalence was 75.74% (95% CI: 71.9%–79.3%).
Md. Abu Sayem, Md. Golam Hossain, Md. Mothashin, Md. Nurul Islam   +3 more
wiley   +1 more source

Unveiling the sedentary epidemic through insights from college students in Guangdong

Scientific Reports
This study investigates the prevalence of sedentary behavior among college students in Guangdong Province, China, and identifies demographic factors associated with sedentary habits.
Xiaoyu Tao, Xuelan Wu, Siying Zhuo, Jia fu, Ying Xiao, Yang Zhao, Junfeng Liao, Tian Zhong   +7 more
doaj   +1 more source