Results 61 to 70 of about 127,239 (304)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Perceptions of sedentary behaviour in people with severe asthma: a qualitative study

BMC Public Health
People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behaviour among ...
Paola D Urroz Guerrero, Peter G Gibson, Hayley Lewthwaite, Eleanor Majellano, Sarah A Hiles, Vanessa M McDonald   +5 more
doaj   +1 more source

Market‐Based Nutrition Regulation and Adult BMI Dynamics in Latin America

Agribusiness, EarlyView.
ABSTRACT Market‐based nutrition policies, including interpretative labeling systems and taxes on sugar‐sweetened beverages (SSBs), have been widely adopted across Latin America to influence dietary choices and address rising obesity rates. While prior research documents change in food purchasing and product reformulation following these policies ...
Emiliano Lopez Barrera, Grace Melo
wiley   +1 more source

Wireless, Battery‐Free Wearable Pressure Sensor for Compression Therapy Entirely Built on Surface Mount Devices

Advanced Intelligent Systems, EarlyView.
This work presents a flexible, battery‐free sensor that forms a closed‐loop feedback system for smart compression therapy devices. Its scalable surface‐mount manufacturing, compact form factor, and wireless communication enable seamless integration with a wide range of active compression garments, improving user experience and therapeutic outcomes ...
Sinuo Zhao, Hongru Chen, Isaac Seeto, Phuoc Thien Phan, Chi Cong Nguyen, Tran Bach Dang, Kefan Zhu, Michael Listyawan, Minh Cuong Duong, Alice Ma, Thanh Nho Do, Hoang‐Phuong Phan   +11 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Exploring the perceptions of sedentary behaviour in community-dwelling older adults aged 75 and older: a series of focus group interviews

BMC Public Health
Background Older adults are the most sedentary and fastest-growing demographic, yet adults aged ≥ 75 years are underrepresented in sedentary behaviour research.
Ragy Tadrous, Anne Forster, Amanda Farrin, Peter A. Coventry, Andrew Clegg   +4 more
doaj   +1 more source

Trends in physical activity and sedentary behaviour in adolescence: ethnic and socioeconomic differences [PDF]

, 2007
Objective: To assess developmental trends in physical activity and sedentary behaviour in British adolescents in relation to sex, ethnicity and socioeconomic status (SES).Design: A 5-year longitudinal study of a diverse cohort of students aged 11 - 12 ...
Boniface, DR, Brodersen, NH, Steptoe, A, Wardle, J   +3 more
core  

Co-creating a tailored public health intervention to reduce older adults’ sedentary behaviour [PDF]

, 2017
Objective: The increasing health care costs associated with an ageing population and chronic disease burden are largely attributable to modifiable lifestyle factors that are complex and vary between individuals and settings.
Chastin, Sebastien F.M., Leask, Calum, Sandlund, Marlene, Skelton, Dawn A.   +3 more
core   +2 more sources

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source