Results 151 to 160 of about 1,705,220 (426)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, Volume 19, Issue 5, Page 1291-1294, May 2025.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Numerical modeling of bamboo fences with various infill porosities deployed for mangrove restoration

Frontiers in Marine Science
As part of mangrove restoration initiatives eco-friendly fence has been implemented in eroded coastal areas in recent years. These fences provide the capacity to mitigate incoming wave energy and facilitate sediment deposition, thereby promoting the ...
Anping Shu, Ziru Zhang, Baoshan Cui, Yiyuan Zhuo, Xin Zhang, Xin Zhang, Chengling Pi, Fuyang Zhu, Huarez Christian   +8 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The shape of fringing tidal flats in engineered estuaries

Frontiers in Marine Science
For the management of estuaries and the preservation of tidal flats it is crucial to understand the tidal flat shape and development. Previous work focused predominantly on the quasi-equilibrium shape of tidal flats along open coasts with a dominant ...
Jill L. J. Hanssen, Jill L. J. Hanssen, Bram C. van Prooijen, Dirk S. van Maren, Dirk S. van Maren   +4 more
doaj   +1 more source

Probabilistic Classification of Near-Surface Shallow-Water Sediments using A Portable Free-Fall Penetrometer [PDF]

arXiv
The geotechnical evaluation of seabed sediments is important for engineering projects and naval applications, offering valuable insights into sediment properties, behavior, and strength. Obtaining high-quality seabed samples can be a challenging task, making in-situ testing an essential part of site characterization.
arxiv  

Topographic Development History of the Alaska Range [PDF]

, 2014
The overall goal of this project is to use variations in sediment source through time as a proxy for deciphering the uplift history of the Alaska Range (Fig. 1).
Davis, Kailyn N.
core  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Erosion and Sedimentation

Eos, Transactions American Geophysical Union, 1971
Research activities in erosion and sedimentation processes have expanded broadly during the past several years and have kept pace with generally accelerated developments in all phases of hydrology and water resources investigations.
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source