Results 161 to 170 of about 1,705,220 (426)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

A Long-Term Evaluation of the Ecohydrological Regime in a Semiarid Basin: A Case Study of the Huangshui River in the Yellow River Basin, China

open access: yesHydrology
This study aimed to evaluate the ecohydrological regime and ecological water demand of the Huangshui River Basin under changing environmental conditions, seeking to safeguard its ecosystem.
Lijuan Fan   +5 more
doaj   +1 more source

Acoustic measurements of boundary layer flux profiles over a sandy rippled bed under regular waves [PDF]

open access: yes, 2009
The study of boundary layer sediment transport processes requires contemporaneous measurements of the bedforms, the flow and the sediment movement. Obtaining these three parameters, at the required temporal-spatial resolutions, has been traditionally ...
Chassagne, Francois, X.   +4 more
core  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Report and preliminary results of RV METEOR Cruise M78/3. Sediment transport off Uruguay and Argentina: from the shelf to the deep sea ; 19.05.2009 – 06.07.2009, Montevideo (Uruguay) – Montevideo (Uruguay) [PDF]

open access: yes, 2012
The waters off Uruguay and Northern Argentina offer the possibility to study sediment transport processes from ‘source-to-sink’ in a relatively small area.
Krastel, Sebastian, Wefer, Gerold
core  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

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