FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Driving factors of runoff and sediment yield effects of various slope ecological restoration measures in the middle reaches of the Yellow River. [PDF]
PeerJWang X +5 more
europepmc +1 more source
The impact of land use and land cover (LULC) dynamics on soil erosion and sediment yield in Ethiopia. [PDF]
Heliyon, 2019 Kidane M, Bezie A, Kesete N, Tolessa T.
europepmc +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
SWAT-based soil erosion and sediment yield modeling in the upper Gilgel Abay catchment, Blue Nile Basin, Ethiopia. [PDF]
Sci RepAlebachew ED +5 more
europepmc +1 more source
Estimating sediment yield at Kaduna watershed, Nigeria using soil and water assessment tool (SWAT) model. [PDF]
Heliyon, 2019 Daramola J +4 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Assessment of sediment yield and accumulation in reservoir: The case of Gibe One Reservoir, Southwestern Ethiopia. [PDF]
HeliyonKuma HG, Chinasho EM, Tolke AA.
europepmc +1 more source
T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ±
Sarah J. Wright +10 more
wiley +1 more source
Seed removal on loess slopes in relation to runoff and sediment yield
, 2011 Overland flow and sediment transport can carry away seeds at the soil surface and in the soil, cause a secondary seed dispersal event, lead to seed redistribution, and influence the spatial distribution of seedling renewal, which plays an important role ...
Jiao Juying +3 more
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