Results 61 to 70 of about 83,571 (346)

Box Models of Volatile Cycles over the Entire Phanerozoic [PDF]

, 2006
Three stand-alone geochemical box models have been developed to simulate globally coupled biogeochemical cycles. These models reflect the evolution of the participating biotic and abiotic constituents in marine and terrestrial environments, including the
Bartdorff, Oliver
core  

Worldwide distribution of continental rock lithology: Implications for the atmospheric/soil CO2 uptake by continental weathering and alkalinity river transport to the oceans [PDF]

, 2003
The silicate rock weathering followed by the formation of carbonate rocks in the ocean, transfers CO2 from the atmosphere to the lithosphere. This CO2 uptake plays a major role in the regulation of atmospheric CO2 concentrations at the geologic ...
Amiotte Suchet, Philippe, Ludwig, Wolfgang, Probst, Jean-Luc   +2 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Sedimentary and evolutionary characteristics of Sinian in the Tarim Basin

Petroleum Research, 2017
Analysis of Sinian outcrops in the peripheral regions of the Tarim Basin, drilling and seismic data within the Tarim Basin, and combined with previous studies, distribution of Sinian strata, tectonic setting, sedimentary system and lithofacies ...
Kaibo Shi, Bo Liu, Weimin Jiang, Xiaoqiao Gao, Shiqi Liu, Yingchu Shen   +5 more
doaj   +1 more source

Timing of initiation of reverse displacement on the Taranaki Fault, northern Taranaki Basin: Constraints from the on land record (Oligocene Te Kuiti Group) [PDF]

, 2008
Structures associated with the wedge of basement overthrust into Taranaki Basin along the Taranaki Fault, are regarded as hydrocarbon plays and have been tested by drilling through the tip of the overthrust.
Kamp, Peter J.J., Tripathi, Anand Ratnakar Prasad   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Sedimentary evolution of an inner foreland basin margin: Paleogene Promina Beds of the type area, Mt. Promina (Dinarides, Croatia)

Geologia Croatica, 2011
            Mt. Promina became famous for its coal mines, vertebrate remains and fossil flora, and for the use of its name in denoting sediments covering a wide area of the Dinaric coastal range.
Jožica Zupanič, Ljubomir Babić
doaj   +1 more source

Development and controlling factors of shale lithofacies cycles in a continental rift basin: A case study of Es4u in the Boxing Subsag of Dongying Sag, Bohai Bay Basin, China

Frontiers in Earth Science, 2023
The shale of the upper Es4 formation (Es4u), deposited during the Eocene in the Boxing Subsag of the Dongying Sag, is a typical set of lime-rich lacustrine shale in a continental rift basin.
Zhengwei Fang, Zhengwei Fang, Zhengwei Fang, Zhengwei Fang, Zhengwei Fang, Liqiang Zhang, Cunfei Ma   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source