Results 31 to 40 of about 26,826 (296)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Neoproterozoic sedimentary deposits of the Tucuruí Group – Araguaia Belt, Northestern of Pará state [PDF]

Geologia USP. Série Científica, 2014
The Tucuruí Group of Neoproterozoic age outcrops in Tucuruí region, northeastern of Pará state, along with the transition between the Amazonian Craton and Araguaia Belt.
Alessandra de Cássia dos Santos Dutra, Paulo Sergio de Sousa Gorayeb, Afonso César Rodrigues Nogueira   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ON THE SEDIMENTARY AND CONSERVATIVE ENVIRON

The Journal of the Japanese Association of Mineralogists, Petrologists and Economic Geologists, 1972
The factors which influence the depositional environment of fossil iron-sand placer deposits are the climate, tectonic regime, general palaeogeographic environments, peculiarities of the source area, and the hydro-dynamic conditions in the front basin.
openaire   +3 more sources

Clay mineralogy in mylonite weathering products from Njimom (west Cameroon): origin and terracotta suitability

Discover Geoscience
This study investigated the mineralogical assemblage of weathering products developed on mylonite rocks in west Cameroon. Smectite and vermiculite occurrence was studied, particularly to emphasize its origin and the potential of the samples in terracotta
A. N. Nzeukou, D. Tsozué, I. Y. Bomeni, J. R. Mache, M. R. Kwopnang, N. Fagel   +5 more
doaj   +1 more source

The Characteristics of Lithofacies and Depositional Model of Fine-Grained Sedimentary Rocks in the Ordos Basin, China

Energies, 2023
In order to clarify the characteristics of fine-grained sedimentary lithofacies and the depositional models in lacustrine environments of the Chang 7 Member of the Upper Triassic Yanchang Formation in the Ordos Basin, we focus on the lacustrine ...
Zhenhong Chen, Xincheng Li, Hao Chen, Zhennan Duan, Zhen Qiu, Xiaoqian Zhou, Yuguang Hou   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dynamical Sedimentary Models of Shallow Marine Environments

, 2001
This treatise represents a contribution of quantitative, dynamical sedimentary modeling to the analytical understanding of sedimentary processes in shallow marine environments.
Zhang, Yong
core   +1 more source