Results 111 to 120 of about 443,219 (282)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

open access: yesAdvanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou   +9 more
wiley   +1 more source

3. Sedimentary rocks

open access: yes, 2016
The Earth has the greatest abundance and variety of sedimentary strata in our star system, dating back some 3.8 billion years. ‘Sedimentary rocks’ describes the processes that create different types of sedimentary rocks, which form a key guideline in ...
Jan Zalasiewicz
core   +1 more source

The source of the gold in Carlin-type gold deposits

open access: yesCommunications Earth & Environment
The source of the gold in Carlin-type deposits has been debated ever since this unusual gold deposit-type was first discovered in the Carlin district of Nevada (USA) more than sixty years ago, with magmatic, metamorphic, sedimentary, and hybrid sources ...
Mingchun Chai   +4 more
doaj   +1 more source

Sedimentary rock

open access: yes, 2008
Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
openaire   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

open access: yesAdvanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert   +8 more
wiley   +1 more source

Pore structure characterization of low permeability rocks [PDF]

open access: yes, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Hoje as pesquisas em rochas de baixa permeabilidade (grande tendência no mundo e em breve ...
Schmitt, Mayka
core  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Solvent Hydrogen Bonding Determines Adsorption Geometry of Trimesic Acid on Cu

open access: yesAngewandte Chemie, EarlyView.
Water reorients adsorbate molecules. Combined tip‐enhanced Raman spectroscopy, density functional theory and molecular dynamics simulations reveal the adsorption geometry of trimesic acid on Cu. Subtle adsorbate–substrate–solvent energy differences due to hydrogen bonding dictate molecular orientation at solid/liquid and solid/gas interfaces, providing
Anusha Lalitha   +4 more
wiley   +2 more sources

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