Results 51 to 60 of about 137,466 (363)

Ichnofossils, Cracks or Crystals? A Test for Biogenicity of Stick-Like Structures from Vera Rubin Ridge, Mars

Geosciences, 2020
New images from Mars rover Curiosity display millimetric, elongate stick- like structures in the fluvio-lacustrine deposits of Vera Rubin Ridge, the depositional environment of which has been previously acknowledged as habitable.
Andrea Baucon, Carlos Neto De Carvalho, Fabrizio Felletti, Roberto Cabella   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Shaken and Stirred: A Comparative Study of Earthquake‐Triggered Soft‐Sediment Deformation Structures in Lake Sediments

Geochemistry, Geophysics, Geosystems
Subaqueous paleoseismic studies used soft sediment deformation structures (SSDS) to discern the shaking strength of past earthquakes, as the deformation degree of SSDS related to Kelvin Helmholtz Instability evolves from disturbed lamination and folds to
Ariana Molenaar, Katleen Wils, Maarten VanDaele, Christoph Daxer, Nathalie Dubois, Anja Grießer, Patrick Oswald, Arne Ramisch, Michael Strasser, Jasper Moernaut   +9 more
doaj   +1 more source

Multiscale structure in sedimentary basins [PDF]

Basin Research, 2004
AbstractHierarchies of superimposed structures are found in maps of geological horizons in sedimentary basins. Mapping based on three‐dimensional (3D) seismic data includes structures that range in scale from tens of metres to hundreds of kilometres. Extraction of structures from these maps without a priori knowledge of scale and shape is analogous to ...
S. A. Stewart, G. J. Hay, P. L. Rosin, T. J. Wynn   +3 more
openaire   +1 more source

Cap rock efficiency of geothermal systems in fold-and-thrust belts: Evidence from paleo-thermal and structural analyses in Rosario de La Frontera geothermal area (NW Argentina) [PDF]

, 2016
Cap rock characterization of geothermal systems is often neglected despite fracturing may reduce its efficiency and favours fluid migration. We investigated the siliciclastic cap rock of Rosario de La Frontera geothermal system (NW Argentina) in order to
Aldega, L., Bigi, S., Chiodi, Agostina Laura, Corrado, Sveva, Di Paolo, L., Giordano, G., Invernizzi, C., Maffucci, R.   +7 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Comment on Reply to Comment of Finger et al. (2013) on: 'Evidence for an Early-Middle Miocene age of the Navidad Formation (central Chile): Paleontological, paleoclimatic and tectonic implications' of Gutiérrez et al. (2013, Andean Geology 40 (1): 66-78) [PDF]

, 2014
Indexación: Web of Science; ScieloIn their answer to our Comment (Finger et al., 2013), Le Roux et al. (2013) misunderstand several of our remarks and present what we view as f lawed arguments, principally their case for a shallow-marine environment for ...
Contardo, Ximena, Encinas, Alfonso, Finger, Kenneth L., Nielsen, Sven N   +3 more
core   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Report of Investigations No. 132 Continuity and Internal Properties of Gulf Coast Sandstones and their Implications for Geopressured Fluid Production [PDF]

, 1983
UT ...
Ewing, T.E., Morton, R.A., Tyler, N.
core   +1 more source