Results 71 to 80 of about 416,729 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Iron inputs from sediments to the oceans [PDF]

, 2009
This thesis explores the nature and ubiquity of iron (Fe) inputs from sediments to theoceans. In the last 10 years continental shelf sediments have become widely recognisedas important vectors for dissolved Fe inputs to the oceans, where bacterial ...
Homoky, William Bela
core   +1 more source

Tool4S: A GUI-based python software tool for seismic station site selection data processing and analysis

SoftwareX
Data quality is the foundation of further research. It’s essential to find a seismic station whose data could be collected without being significantly affected by surrounding noise sources.
Cheng Ding, Chengli Jiao, Shuang Zheng, Zhiyuan Zhao, Xiangdong Feng   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Speciation of Sedimentary Phosphorus in an Urban Wetland: The Case of El Oulfa Pound. Casablanca, Morocco [PDF]

E3S Web of Conferences
Eutrophication remains a major concern for the quality of surface waters worldwide. This phenomenon significantly restricts water usage. The El Oulfa pond, located in Casablanca, is experiencing advanced eutrophication primarily caused by domestic ...
Nachchach Badr, Jounaid Halima, Taoufik Mohammed, Chakri Nihad, Elamrani Btissam, Dialo Wandé   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Dynamics of Trace Metal Interactions with Authigenic Sulfide Minerals in Anoxic Sediments

, 1995
pgs. 187-199Sediments are the dominant sink for trace metals of environmental concern in most aquatic environments. It is consequently important to understand the chemical behavior of trace metals in sediments in order to assess their potential impact on
Morse, John W.
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Short-term fate of phytodetritus in sediments across the Arabian Sea Oxygen Minimum Zone [PDF]

, 2007
The short-term fate of phytodetritus was investigated across the Pakistan margin of the Arabian Sea at water depths ranging from 140 to 1850 m, encompassing the oxygen minimum zone (~100–1100 m).
Middelburg, J.J., Soetaert, K.E.R., Levin, L. A., Andersson, J.H., Woulds, C., G. L. Cowie, L. A. Levin, Cowie, G.L., Levin, L.A., Soetaert, K., Middelburg, J. J., J. H. Andersson, Schwartz, M., Cowie, Gregory, K. Soetaert, M. Schwartz, J. J. Middelburg, Andersson, J. H., C. Woulds, Cowie, G. L.   +19 more
core   +3 more sources