Results 81 to 90 of about 437,331 (302)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Apparent OSL ages of modern deposits from Fåbergstølsdalen, Norway : implications for sampling glacial sediments [PDF]

, 2013
This work was funded by NERC, grant number F008589/1The application of optically stimulated luminescence (OSL) dating within glacial settings can be limited where sediments have not had their OSL signal fully reset by sunlight exposure.
Robinson, Ruth Alison Joyce, A. A. FINCH, King, Georgina, G. E. KING, Finch, Adrian Anthony, R. A. J. ROBINSON, Finch, Adrian Anthony; id_orcid   +6 more
core   +1 more source

Seagrass (Zostera marina) promotes nitrification potential and selects specific ammonia oxidizers in coastal sediments

, 2021
Purpose Seagrasses accelerate sedimentation, release oxygen and organic matter through their roots, and compete with ammonia oxidizers for ammonia/ammonium in surface sediments and overlying water, all of which can influence benthic aerobic nitrification.
Zou, Songbao, Lin, Xianbiao, Zheng, Pengfei, Gong, Jun, Zhang, Xiaoli, Sun, Feifei, Feifei Sun, Xiaoli Zhang, Jun Gong, Songbao Zou, Xianbiao Lin, Pengfei Zheng   +11 more
core   +1 more source

Assessing the effects of model parameter assumptions on surface-wave inversion resultsKey points

Earthquake Science
Surface-wave inversion is a powerful tool for revealing the Earth’s internal structure. However, aside from shear-wave velocity (vS), other parameters can influence the inversion outcomes, yet these have not been systematically discussed.
Xuezhen Zhang, Xiaodong Song
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Type Specimens of the Species of the Genus Papillicalymene (Arthropoda, Trilobita) from Ukraine Described by Leonid Konstantynenko

Zoodiversity
The article presents diagnoses and information on the type series of two trilobite species of the genus Papillicalymene Shirley, 1936: P. dnistroviana Konstantynenko, 2006 and P. sokoliana Konstantynenko, 2006 from the Ludlow (Upper Silurian) of Podillia
V. Dernov
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Dynamics of Trace Metal Interactions with Authigenic Sulfide Minerals in Anoxic Sediments

, 1995
pgs. 187-199Sediments are the dominant sink for trace metals of environmental concern in most aquatic environments. It is consequently important to understand the chemical behavior of trace metals in sediments in order to assess their potential impact on
Morse, John W.
core  

Characterization of Deformation Driven by the South-to-North Water Diversion and Extreme Rainfall Along the Taihang Piedmont Using Time-Series InSAR

Remote Sensing
Long-term groundwater overexploitation in the North China Plain has triggered severe land subsidence. Meanwhile, the implementation of the Middle Route of the South-to-North Water Diversion (SNWD) project and extreme precipitation events driven by ...
Weilai Sun, Teng Wang, Na Luo, Xiaotao Zhang   +3 more
doaj   +1 more source

Detailed seismic velocity of the incoming subducting sediments in the 2004 great Sumatra earthquake rupture zone from full waveform inversion of long offset seismic data

Geophysical Research Letters, 2017
The nature of incoming sediments defines the locking mechanism on the megathrust, and the development and evolution of the accretionary wedge. Here we present results from seismic full waveform inversion of 12 km long offset seismic reflection data ...
Yanfang Qin, Satish C. Singh
doaj   +1 more source