Results 51 to 60 of about 101,767 (267)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Assessing the effects of model parameter assumptions on surface-wave inversion resultsKey points

Earthquake Science
Surface-wave inversion is a powerful tool for revealing the Earth’s internal structure. However, aside from shear-wave velocity (vS), other parameters can influence the inversion outcomes, yet these have not been systematically discussed.
Xuezhen Zhang, Xiaodong Song
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Type Specimens of the Species of the Genus Papillicalymene (Arthropoda, Trilobita) from Ukraine Described by Leonid Konstantynenko

Zoodiversity
The article presents diagnoses and information on the type series of two trilobite species of the genus Papillicalymene Shirley, 1936: P. dnistroviana Konstantynenko, 2006 and P. sokoliana Konstantynenko, 2006 from the Ludlow (Upper Silurian) of Podillia
V. Dernov
doaj   +1 more source

Detailed seismic velocity of the incoming subducting sediments in the 2004 great Sumatra earthquake rupture zone from full waveform inversion of long offset seismic data

Geophysical Research Letters, 2017
The nature of incoming sediments defines the locking mechanism on the megathrust, and the development and evolution of the accretionary wedge. Here we present results from seismic full waveform inversion of 12 km long offset seismic reflection data ...
Yanfang Qin, Satish C. Singh
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Characterization of Deformation Driven by the South-to-North Water Diversion and Extreme Rainfall Along the Taihang Piedmont Using Time-Series InSAR

Remote Sensing
Long-term groundwater overexploitation in the North China Plain has triggered severe land subsidence. Meanwhile, the implementation of the Middle Route of the South-to-North Water Diversion (SNWD) project and extreme precipitation events driven by ...
Weilai Sun, Teng Wang, Na Luo, Xiaotao Zhang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source