Results 81 to 90 of about 100,674 (267)

Chemical Forms and Distribution Characteristics of Phosphorus in the Sediments of the Anning Phosphate Mining Area, Yunan Province

Yankuang ceshi
The chemical forms and content of phosphorus in sediments are the important basis for exploring bioavailability, migration, and transformation of phosphorus in sediments accurately.
Wei LIU, Jundong HU, Chenzi FAN, Yongbing LIU, Wenbo ZHAO, Chenghai LIU   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Impacts of LULC and climate change on runoff and sediment production for the Puyango-Tumbes basin (Ecuador-Peru)

Frontiers in Remote Sensing
Climate change will cause alterations in the hydrological cycle, a topic of great relevance to the scientific community due to its impacts on water resources.
Robinson Peña-Murillo, Waldo Lavado-Casimiro, Waldo Lavado-Casimiro, Luc Bourrel   +3 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

RETRACTED: Assessing Mercury Contamination Levels in the Sediments of Two Pyrenean Lakes

Diversity
Mercury, a trace metal, is a persistent environmental pollutant that can be detected even in remote regions, including high-mountain lakes. This study examined mercury concentrations in the sediment of two lakes in the French Pyrenees, the Legunabens and
Cristian Yoel Quintero-Castañeda, Luis Roberto Hernández-Angulo, Daniel Tobón-Vélez, Anamaría Franco-Leyva, María Margarita Sierra-Carrillo   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Sedimentation of microplastics interacting with sediment

The widespread presence of microplastics (MPs) in freshwater environments underscores the need to better understand their temporal and spatial dynamics. Investigating the settling velocity (W) of MPs in the water column is crucial for comprehending their transport mechanisms within river systems.
Mancini, Mirco, Serra, Teresa, Colomer, Jordi, Francalanci, Simona, Solari, Luca   +4 more
openaire   +1 more source