A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Cadmium transport in sediments by tubificid bioturbation: An assessment of model complexity [PDF]
, 2006 Biogeochemistry of metals in aquatic sediments is strongly influenced by bioturbation. To determine the effects of biological transport on cadmium distribution in freshwater sediments, a bioturbation model is explored that describes the conveyor-belt ...
Boudou, A. +11 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Hydrothermal sediments record changes in deep water oxygen content in the SE Pacific
, 2010 The distribution of redox?sensitive metals in sediments is potentially a proxy for past ocean ventilation and productivity, but deconvolving these two major controls has proved difficult to date.
John Thomson +7 more
core +1 more source
Earthquake ScienceSeismic attenuation is a fundamental property of the Earth's media. Attenuation structure for the complicated geological structures with strong seismicity in the Sichuan-Yunnan region is poorly studied. In this study, we collected 108,399 waveforms of 11,
Tian Li +6 more
doaj +1 more source
The Bivalve Corbicula fluminalis (Müller, 1774): an Indicator for Heavy Metals Accumulation in the Habitat of Zayandeh-Roud River [PDF]
بومشناسی آبزیان, 2016 The accumulation of the heavy metals Cd, Zn, Cu, and Pb were surveyed in the samples of mantle tissues, crusts and so the habitat sediments of C. fluminalis to reveal the probable biomonitoring rule of the bivalve in the ecosystem.
Hourieh Movahedi +3 more
doaj
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Heavy metal distribution in recent sediments along the Tietê River basin (São Pauro, Brazil) [PDF]
, 2011 The distribution of heavy metals in recent sediments deposited along the Tietê River, a highly polluted river in southeast region of Brazil was studied.
Probst, Jean-Luc +2 more
core
Microbial Colonization of Minerals in Marine Sediments – Method Development and Ecological Significance [PDF]
, 2011 Interactions between microorganisms and minerals significantly impact microbial diversity and geochemical cycles in diverse settings. However, methodological difficulty has inhibited past study of microbe–mineral interactions in fine-grained subsurface ...
Harrison, Benjamin Kimball
core +1 more source
Moment magnitude of Myanmar earthquake on March 28, 2025 from long-period seismic codaKey points
Earthquake ScienceOn March 28, 2025, a large earthquake struck central Myanmar and caused massive damage and casualties. The magnitude of the mainshock is a fundamental parameter that both the general public and scientific communities are concerned about.
Tian Li, Xiaodong Song
doaj +1 more source