Results 111 to 120 of about 417,252 (301)
ToxicsThe mechanisms driving changes in the stability of phosphorus (P) in sediments under lake ecosystem degradation remain poorly understood. This study investigated the P-binding forms in sediments from three plateau lakes with different trophic states in ...
Xue Wu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The depth specific significiance, relative abundance and phylogeography of anaerobic ammonium oxidation (anammox) in marine and estuarine sediments [PDF]
, 2009 PhDThe availability of fixed forms of nitrogen is critical to the regulation of primary production. Until recently, denitrification (the sequential reduction of NO3 -, through NO2 - , to di-nitrogen gas) was recognised as the only significant pathway
Rooks, Christine
core +2 more sources
Yankuang ceshiThe chemical forms and content of phosphorus in sediments are the important basis for exploring bioavailability, migration, and transformation of phosphorus in sediments accurately.
Wei LIU +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Frontiers in Remote SensingClimate change will cause alterations in the hydrological cycle, a topic of great relevance to the scientific community due to its impacts on water resources.
Robinson Peña-Murillo +3 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
RETRACTED: Assessing Mercury Contamination Levels in the Sediments of Two Pyrenean Lakes
DiversityMercury, a trace metal, is a persistent environmental pollutant that can be detected even in remote regions, including high-mountain lakes. This study examined mercury concentrations in the sediment of two lakes in the French Pyrenees, the Legunabens and
Cristian Yoel Quintero-Castañeda +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source