Results 111 to 120 of about 416,729 (302)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The measurement of the in situ compressional wave properties of marine sediments [PDF]

, 2007
Geoacoustic inversion requires a generic knowledge of the frequency-dependence of compressional wave properties in marine sediments, the nature of which is still under debate. The use of in situ probes to measure sediment acoustic properties introduces a
Dix, J.K., Best, A.I., Leighton, T.G., White, P.R., Bull, J.M., Harris, A., Robb, G.B.N.   +6 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Assessment main of the oil and gas source properties of the jurassic rocks of the tersko-caspian foredeep

Наука. Инновации. Технологии, 2022
The study of the organic matter (OM) of rocks of the deposits of the Tersko-Caspian foredeep (TCF) on the basis of luminescent and chemical-bituminous analyzes was carried out.
Anatoly Andreevich Yaroshenko, Anna Aleksandrovna Paporotnaya, Julia Andreevna Savina, Olesia Vladimirovna Skripnyuk   +3 more
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Bacterial GDGTs in Holocene sediments and catchment soils of a high Alpine lake: application of the MBT/CBT-paleothermometer [PDF]

, 2011
A novel proxy for continental mean annual air temperature (MAAT) and soil pH, the MBT/CBT-paleothermometer, is based on the temperature (T) and pH-dependent distribution of specific bacterial membrane lipids (branched glycerol dialkyl glycerol ...
Lehmann, M. F., Hopmans, E.C., Stadnitskaia, A., Hopmans, Ellen C., J. S. Sinninghe Damsté, Niemann, Helge, Anselmetti, Flavio S., Sinninghe-Damste, J.S., Stadtnitskaia, A., A. Gilli, Wirth, Stefanie B., Niemann, H., F. S. Anselmetti, M. F. Lehmann, A. Stadnitskaia, E. C. Hopmans, Sinninghe Damsté, J.S.S., Sinninghe Damsté, Jaap S., Lehmann, M.F., Schouten, S., H. Niemann, Sinninghe Damsté, J.S., Stadnitskaia, Alina, S. B. Wirth, Wirth, S.B., Hoppmans, E. C., Schouten, Stefan, Gilli, A., Wirth, S. B., Sinninghe Damsté, J. S., Anselmetti, F.S., Anselmetti, F. S., Lehmann, Moritz F., S. Schouten, Gilli, Adrian; id_orcid   +34 more
core   +4 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source