Results 71 to 80 of about 155,966 (283)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The peculiarities of sorghum seed-growing in the Rostov region

Зерновое хозяйство России, 2018
The peculiarities of sorghum seed-growing in the Rostov region To obtain high-qualitative seeds it’s necessary to improve seed-growing and to follow all recommendations concerning cultivation technology, harvesting, after-harvesting seed processing and ...
S. I. Gorpinichenko, N. A. Kovtunova, E. A. Shishova, G. M. Ermolina, A. E. Romanyukin   +4 more
doaj   +1 more source

Analysis the farm-level diversification and market position of the Hungarian organic products [PDF]

, 2014
In Hungary 1560 farms were involved in the organic farming in 2012. According to the producers' list of the Hungarian Federation of Associations for Organic Farming, on which 1126 members were registered, Pest, Szabolcs-Szatmár-Bereg, Hajdú-Bihar and ...
Nagyné Pércsi, Kinga, Szabó, Virág
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Large-Scale Discovery of Spatially Related Images [PDF]

, 2010
We propose a randomized data mining method that finds clusters of spatially overlapping images. The core of the method relies on the min-Hash algorithm for fast detection of pairs of images with spatial overlap, the so-called cluster seeds. The seeds are
Chum, Ondřej, Matas, Jiří
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A novel neural network approach to cDNA microarray image segmentation [PDF]

, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below. Copyright @ 2013 Elsevier.Microarray technology has become a great source of information for biologists to understand the workings of DNA ...
Adams, Bachar Zineddin, Bajcsy, Bishop, Blekas, Blekas, Bozinov, Bozinov, Buckley, Burt, Demirkaya, Demuth, DeRisi, DeRisi, Eisen, Fausett, Fraser, Fraser, Ham, Haykin, Hebb, Jain, Jie Cao, Jinling Liang, Katzer, Lawrence, Lehmussola, Li, Liao, Lukac, Lukac, Mata, MathWorks, McCulloch, Min Du, Moore, Morris, Nianyin Zeng, Noda, Orengo, Otsu, Schena, Srinark, Tran, Wang, Wang, Whitchurch, Wit, Xiaohui Liu, Yang, Yurong Li, Zidong Wang, Zineddin   +52 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Volume and densities of chronic subdural haematoma obtained from CT imaging as predictors of postoperative recurrence: a prospective study of 107 operated patients [PDF]

, 2012
BACKGROUND: Chronic subdural haematoma (CSDH) is a common entity in neurosurgery with a considerable postoperative recurrence rate. Computerised tomography (CT) scanning remains the most important diagnostic test for this disorder.
Are Hugo Pripp, Frode Kolstad, Inge Andre Rasmussen, Jarle Sundseth, John Hald, Jugoslav Ivanović, Karl-Fredrik Lindegaard, Mark Züchner, Milo Stanišić   +8 more
core   +1 more source