Results 111 to 120 of about 405,391 (297)
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Seed bank persistence of clonal weeds in contrasting habitats: implications for control [PDF]
, 2018 The ability of weeds to form a seed bank is important for their population dynamics and management because it provides a refuge enabling reinvasion after established target plants have died.
Hesse, Elze +2 more
core
Advanced Science, EarlyView.RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng +6 more
wiley +1 more source
Introduction of Seed Accumulation Index as new approach in soil seed bank classification
تاکسونومی و بیوسیستماتیک, 2013 The purpose of this study was the introduction of seed accumulation index as a new approach in the evaluation of soil seed bank consistency in the Populus caspica in Noor reserved forest park. Sampling were made above ground vegetation at peak vegetation
Azam Noraiy +3 more
doaj
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Bacteria-phage coevolution with a seed bank. [PDF]
ISME J, 2023 Schwartz DA +4 more
europepmc +1 more source
Benefits of Improved Groundnut Technologies to Resource-poor Farmers: A Participatory Approach [PDF]
Considering that non-adoption of improved groundnut technologies by the small and resource-poor farmers is due to non-availability of quality seeds, poor knowledge, inappropriateness of technologies, etc., in the current study, improved groundnut ...
Basu, M.S. +2 more
core +1 more source
Peran Celah Antar Tajuk Tegakan dan Seed Bank Tanah terhadap Regenerasi Hutan [PDF]
, 2013 . This research aimed to estimated seed composition in seed bank and detected ability of growing at some gaps measures between strightened coronets in fields. Seed emergence energy in seed bank in field only 49 % from all the viable seed.
Utomo, B. (Budi)
core +1 more source
Advanced Science, EarlyView.This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche +21 more
wiley +1 more source