Results 231 to 240 of about 405,391 (297)
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao +10 more
wiley +1 more source
Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation
Advanced Science, EarlyView.PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Seed banks and seed dispersal: important topics in restoration ecology§
Acta Botanica Neerlandica, 1996Restoration ecology deals with the scientific and ecological background of nature management practices aiming at the re-establishment of plant species which have disappeared. As we focus on semi-natural landscapes, these disappearances can be caused by intensification of agricultural practices or cessation of human interference.
Bakker, J.P. +4 more
openaire +2 more sources
Improving soil seed bank management
Pest Management Science, 2018AbstractProblems associated with simplified weed management motivate efforts for diversification. Integrated weed management uses the fundamentals of weed biology and applied ecology to provide a framework for diversified weed management programs; the soil seed bank comprises a necessary part of this framework.
Steven C Haring, Michael L Flessner
openaire +2 more sources
2009
The soil seed bank refers to a reservoir of viable seeds present on the soil surface or buried in the soil. It has the potential to augment or replace adult plants. Such reservoirs have regular inputs and outputs. Outputs are losses of seeds by germination, predation or other causes, while inputs include dispersal of fresh seeds from local sources and ...
openaire +1 more source
The soil seed bank refers to a reservoir of viable seeds present on the soil surface or buried in the soil. It has the potential to augment or replace adult plants. Such reservoirs have regular inputs and outputs. Outputs are losses of seeds by germination, predation or other causes, while inputs include dispersal of fresh seeds from local sources and ...
openaire +1 more source
TSitologiia i genetika, 2007
We have found that a progressive loss of telomeric sequences occurs from high molecular weight DNA with an increasing appearance at low molecular weight as the periods of storage in the dry state were extended in time to provide seed germination loss from 98 to 0%.
I, Boubriak +3 more
openaire +4 more sources
We have found that a progressive loss of telomeric sequences occurs from high molecular weight DNA with an increasing appearance at low molecular weight as the periods of storage in the dry state were extended in time to provide seed germination loss from 98 to 0%.
I, Boubriak +3 more
openaire +4 more sources
1989
In part three, on vegetation dynamics, it appeared that many species have become newly established in permanent plots in the study areas. Newly established species in a lot can have been present in the seed bank in the soil before emergence. This is only the case for species with a persistent seed bank sensu Thompson & Grime (1979).
openaire +1 more source
In part three, on vegetation dynamics, it appeared that many species have become newly established in permanent plots in the study areas. Newly established species in a lot can have been present in the seed bank in the soil before emergence. This is only the case for species with a persistent seed bank sensu Thompson & Grime (1979).
openaire +1 more source