Results 41 to 50 of about 405,391 (297)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Using the optimal seed germination temperature approach to determine the potential distribution of Inga jinicuil in Mexico under climate change scenarios

Scientific Reports
Inga jinicuil is used extensively in shade coffee farms in Mexico, a diversified agroforestry system providing important environmental goods and services. However, its recalcitrant seeds represent an important barrier to its propagation.
Salvador Sampayo-Maldonado, Daniel Cabrera-Santos, Patricia Dávila-Aranda, Norma Isela Rodríguez-Arévalo, Alma Orozco-Segovia, Maraeva Gianella, Elizabeth Bell, Michael Way, Robert H. Manson, Gabina S. Quintas, Cesar M. Flores-Ortíz, Tiziana Ulian   +11 more
doaj   +1 more source

Development of a Non-Destructive Tool Based on E-Eye and Agro-Morphological Descriptors for the Characterization and Classification of Different Brassicaceae Landraces

Applied Sciences, 2023
In recent years, Brassicaceae have piqued the interest of researchers due to their extremely rich chemical composition, particularly the abundance of antioxidants and anti-inflammatory compounds, as well as because of their antimutagenic and potential ...
Alessandra Biancolillo, Rossella Ferretti, Claudia Scappaticci, Martina Foschi, Angelo Antonio D’Archivio, Marco Di Santo, Luciano Di Martino   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Rhododendron maximum impacts seed bank composition and richness following Tsuga canadensis loss in riparian forests

Ecosphere, 2018
Southern Appalachian riparian forests have undergone changes in composition and function from invasive pathogens and pests. Castanea dentata mortality in the 1930s from chestnut blight (Cryphonectria parasitica) and Tsuga canadensis mortality in the ...
Tristan M. Cofer, Katherine J. Elliott, Janis K. Bush, Chelcy F. Miniat   +3 more
doaj   +1 more source

Effects of water level on three wetlands soil seed banks on the Tibetan Plateau. [PDF]

PLoS ONE, 2014
BACKGROUND: Although the effect of water level on germination in soil seed banks has been documented in many ecosystems, the mechanism is not fully understood, and to date no empirical studies on this subject exist.
Miaojun Ma, Zhen Ma, Guozhen Du
doaj   +1 more source

Green Chemometric-Assisted Characterization of Common and Black Varieties of Celery

Molecules, 2023
Celery (Apium graveolens L., var. Dulce), is a biennial herbaceous plant belonging to the Apiaceae family, cultivated in humid soils in the Mediterranean basin, in Central-Southern Europe, and in Asia.
Alessandra Biancolillo, Martina Foschi, Leila D’Alonzo, Valter Di Cecco, Marco Di Santo, Luciano Di Martino, Angelo Antonio D’Archivio   +6 more
doaj   +1 more source

Change of the weed seed bank during the first four years of a five-course crop rotation with organic vegetables [PDF]

, 2008
In a five-course rotation with organic vegetables (white cabbage, carrot and onion) the weed seed bank was reduced the year after two continuous years with red clover, mainly because of mowing of the second year red clover.
Brandsæter, Lars Olav, Seljåsen, Randi, Sjursen, Helge   +2 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source