Results 51 to 60 of about 405,879 (301)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Flora, life form and chorological study of soil seed bank in Sisangan box tree (Buxus hyrcanus Pojark) Forest Reserve [PDF]

Zīst/shināsī-i Giyāhī-i Īrān, 2014
The present study involves the soil seed bank flora of the Sisangan Box tree (Buxus hyrcanus Pojark) reserve by using seedling emergence method. 150 soil samples were collected during late June and early November by hammering a hollow metal frame 400 cm2
Moslem Akbarinia, Fereshteh Basseri, Omid Esmailzadeh   +2 more
doaj  

Green Chemometric-Assisted Characterization of Common and Black Varieties of Celery

Molecules, 2023
Celery (Apium graveolens L., var. Dulce), is a biennial herbaceous plant belonging to the Apiaceae family, cultivated in humid soils in the Mediterranean basin, in Central-Southern Europe, and in Asia.
Alessandra Biancolillo, Martina Foschi, Leila D’Alonzo, Valter Di Cecco, Marco Di Santo, Luciano Di Martino, Angelo Antonio D’Archivio   +6 more
doaj   +1 more source

Seed dormancy cycling and the regulation of dormancy mechanisms to time germination in variable field environments [PDF]

, 2017
Many molecular mechanisms that regulate dormancy have been identified individually in controlled laboratory studies. However, little is known about how the seed employs this complex suite of mechanisms during dormancy cycling in the variable environment ...
Finch-Savage, William E., Footitt, Steven   +1 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Differential role of a persistent seed bank for genetic variation in early vs. late successional stages.

PLoS ONE, 2018
Persistent seed banks are predicted to have an important impact on population genetic processes by increasing effective population size and storing past genetic diversity.
Benjamin Schulz, Walter Durka, Jiří Danihelka, Rolf Lutz Eckstein   +3 more
doaj   +1 more source

Seasonal dynamics of the plant community and soil seed bank along a successional gradient in a subalpine meadow on the Tibetan Plateau.

PLoS ONE, 2013
BackgroundKnowledge about how change the importance of soil seed bank and relationship between seed mass and abundance during vegetation succession is crucial for understanding vegetation dynamics.
Miaojun Ma, Xianhui Zhou, Wei Qi, Kun Liu, Peng Jia, Guozhen Du   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Tahitian chestnut [Inocarpus fagifer (Parkinson ex F.A.Zorn) Fosberg, Fabaceae], a neglected multi-purpose tree from the Asia–Pacific region

Discover Agriculture
The Tahitian (or Polynesian) chestnut Inocarpus fagifer is distributed widely in tropical South-East Asia and in the Pacific region. It is an important component in traditional agroforestry systems.
Jonas V. Müller
doaj   +1 more source