Results 161 to 170 of about 23,256 (307)

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu   +23 more
wiley   +1 more source

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama   +17 more
wiley   +1 more source

Root Meristem Maintenance Mechanisms are Key to Plant Defense Against Nanoplastics

open access: yesAdvanced Science, EarlyView.
Small nanoplastics can disrupt cell integrity and inhibit cell division in meristem zone of plant root. The plants can counteract the cell damage by upregulating genes associated with root meristem maintenance and increasing auxin accumulation by PIN2 transport inhibition.
Sirui Ma   +7 more
wiley   +1 more source

Anaerobic Respiration in the Dormancy of Rice Seed

open access: bronze, 1975
Yoshiki Kono   +3 more
openalex   +2 more sources

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

open access: yesAdvanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang   +8 more
wiley   +1 more source

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